ReviewHeart failure reviews2000
N-Cadherin: structure, function and importance in the formation of new intercalated disc-like cell contacts in cardiomyocytes.
Review in Heart failure reviews, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed, 62 citations in OpenAlex.
- Shared and specific blood biomarkers for multimorbidity.Nature medicine · 2026Article
- Role of Mesenchymal Markers in Colorectal Cancer Metastasis.Molecular biology reports · 2025Review
- Long-term engraftment and maturation of autologous iPSC-derived cardiomyocytes in two rhesus macaques.Cell stem cell · 2024Article
- Essential role of obscurin kinase-1 in cardiomyocyte coupling via N-cadherin phosphorylation.JCI insight · 2024Article
- Cardiomyocyte-specific deletion of β-catenin protects mouse hearts from ventricular arrhythmias after myocardial infarction.Scientific reports · 2021Article
- Specific N-cadherin-dependent pathways drive human breast cancer dormancy in bone marrow.Life science alliance · 2021Article
- Carbon Nanotube-Based Scaffolds for Cardiac Tissue Engineering-Systematic Review and Narrative Synthesis.Bioengineering (Basel, Switzerland) · 2021Review
- Engineering aligned human cardiac muscle using developmentally inspired fibronectin micropatterns.Scientific reports · 2021Article
- De Novo Pathogenic Variants in N-cadherin Cause a Syndromic Neurodevelopmental Disorder with Corpus Collosum, Axon, Cardiac, Ocular, and Genital Defects.American journal of human genetics · 2019Article
- Maturation of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes by Soluble Factors from Human Mesenchymal Stem Cells.Molecular therapy : the journal of the American Society of Gene Therapy · 2018Article
- Pharmacogenomics study on cadherin 2 network with regard to HIV infection and methadone treatment outcome.PloS one · 2017Article
- Three-dimensional structure of the intercalated disc reveals plicate domain and gap junction remodeling in heart failure.Biophysical journal · 2015Article
- Acute slowing of cardiac conduction in response to myofibroblast coupling to cardiomyocytes through N-cadherin.Journal of molecular and cellular cardiology · 2014Article
- Arginylation-dependent regulation of a proteolytic product of talin is essential for cell-cell adhesion.The Journal of cell biology · 2012Article
- N-cadherin determines individual variations in the therapeutic efficacy of human umbilical cord blood-derived mesenchymal stem cells in a rat model of myocardial infarction.Molecular therapy : the journal of the American Society of Gene Therapy · 2012Article
- Article
- T-cadherin is critical for adiponectin-mediated cardioprotection in mice.The Journal of clinical investigation · 2010Article
- Green tea extract given before regional myocardial ischemia-reperfusion in rats improves myocardial contractility by attenuating calcium overload.Pflugers Archiv : European journal of physiology · 2010Article
- Implantation of mouse embryonic stem cell-derived cardiac progenitor cells preserves function of infarcted murine hearts.PloS one · 2010Article
- Intercalated discs: multiple proteins perform multiple functions in non-failing and failing human hearts.Biophysical reviews · 2009Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
N-Cadherin belongs to a superfamily of calcium-dependent transmembrane adhesion proteins. It mediates adhesion in the intercalated discs at the termini of cardiomyocytes thereby serving as anchor for myofibrils at cell-cell contacts. A large body of data on the molecular structure and function of N-cadherin exists, however, little is known concerning spatial and temporal interactions between the different junctional structures during formation of the intercalated disc and its maturation in postnatal development. The progression of compensated left ventricular hypertrophy to congestive left heart failure is accompanied by intercalated disc remodeling and has been demonstrated in animal models and in patients. The long-term culture of adult rat cardiomyocytes allows to investigate the development of de novo intercalated disc-like structures. In order to analyze the dynamics of the cytoskeletal redifferentiation in living cells, we used the expression of chimeric proteins tagged with the green fluorescent protein reporter. This technique is becoming a routine method in basic research and complements video time-lapse and confocal microscopy. Cultured cardiomyocytes have been used for a variety of studies in cell biology and pharmacology. Their ability to form an electrically coupled beating tissue-like network in culture possibly allows reimplantation of such cells into injured myocardium, where they eventually will form new contacts with the healthy muscle tissue. Several groups have already shown that cardiomyocytes can be grafted successfully into sites of myocardial infarcts or cryoinjuries. Autologous adult cardiomyocyte implantation, might indeed contribute to cardiac repair after infarction, thanks to advances in tissue engineering.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.