ArticlePhotosynthesis research2004
ADP-Glucose Pyrophosphorylase: A Regulatory Enzyme for Plant Starch Synthesis.
Article in Photosynthesis research, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 106 papers.
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Who cites it
106 citing papers in PubMed, 311 citations in OpenAlex.
- Genome-Wide Analysis of AGPase IdentifiesInternational journal of molecular sciences · 2026Article
- Structure and mechanism of the heterotetrameric ADP-glucose pyrophosphorylase essential for starch synthesis in plants.Science advances · 2026Article
- Investigation into the Anti-hyperglycemic Traits and Bioactive Constituents of Postbiotics Derived from Lacticaseibacillus paracasei NCUH012072.Probiotics and antimicrobial proteins · 2026Article
- Molecular mechanisms and evolutionary adaptations of transporters for photosynthates and specialized metabolites in plants.Plant cell reports · 2026Review
- Proteomic Analysis of Lotus-DerivedPlants (Basel, Switzerland) · 2026Article
- DpAGPs overexpression enhanced application value of Dunaliella Parva for bioethanol production.World journal of microbiology & biotechnology · 2026Article
- Effects of foliar nitrogen application on morphological and physiological characteristics in newly emerged leaves ofFrontiers in plant science · 2026Article
- Deciphering intra-connectivity of gene network response to drought and salinity in apple.Frontiers in plant science · 2026Article
- Deciphering the tight metabolite-level regulation of glucose-1-phosphate adenylyltransferase (GlgC) for glycogen synthesis in cyanobacteria.The FEBS journal · 2025Article
- Genome-Wide Association Study of Sweet Potato Storage Root Traits Using GWASpoly, a Gene Dosage-Sensitive Model.International journal of molecular sciences · 2024Article
- The Developmental Cycle ofPlants (Basel, Switzerland) · 2024Review
- Genetically manipulated chloroplast stromal phosphate levels alter photosynthetic efficiency.Plant physiology · 2024Article
- Characterization of Two Glycoside Hydrolases of Family GH13 and GH57, Present in a Polysaccharide Utilization Locus (PUL) ofMolecules (Basel, Switzerland) · 2024Article
- Peanut leaf transcriptomic dynamics reveals insights into the acclimation response to elevated carbon dioxide under semiarid conditions.Frontiers in plant science · 2024Article
- The OsNAC24-OsNAP protein complex activates OsGBSSI and OsSBEI expression to fine-tune starch biosynthesis in rice endosperm.Plant biotechnology journal · 2023Article
- Light Intensity Affects the Assimilation Rate and Carbohydrates Partitioning in Spinach Grown in a Controlled Environment.Plants (Basel, Switzerland) · 2023Article
- Characterization and Transcriptome Analysis of Maize Small-Kernel MutantPlants (Basel, Switzerland) · 2023Article
- Co-Expression of Lipid Transporters Simultaneously Enhances Oil and Starch Accumulation in the Green MicroalgaMetabolites · 2023Article
- Effect of calcium and magnesium on starch synthesis in maize kernels and its physiological driving mechanism.Frontiers in plant science · 2023Article
- Transcriptomic and metabolomic profiling reveals the drought tolerance mechanism ofFrontiers in plant science · 2023Article
46 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In plants, the synthesis of starch occurs by utilizing ADP-glucose as the glucosyl donor for the elongation of alpha-1,4-glucosidic chains. In photosynthetic bacteria the synthesis of glycogen follows a similar pathway. The first committed step in these pathways is the synthesis of ADP-glucose in a reaction catalyzed by ADP-glucose pyrophosphorylase (ADPGlc PPase). Generally, this enzyme is allosterically regulated by intermediates of the major carbon assimilatory pathway in the respective organism. In oxygenic photosynthesizers, ADPGlc PPase is mainly regulated by 3-phosphoglycerate (activator) and inorganic orthophosphate (inhibitor), interacting in four different patterns. Recent reports have shown that in higher plants, some of the enzymes could also be redox regulated. In eukaryotes, the enzyme is a heterotetramer comprised of two distinct subunits, a catalytic and a modulatory subunit. The latter has been proposed as related to variations in regulation of the enzyme in different plant tissues. Random and site-directed mutagenesis experiments of conserved amino acids revealed important residues for catalysis and regulation. Prediction of the ADPGlc PPase secondary structure suggests that it shares a common folding pattern to other sugar-nucleotide pyrophosphorylases, and they evolved from a common ancestor.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.