ArticleDer Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen2005
[Esophagectomy as therapeutic principle for squamous cell esophageal cancer].
Article in Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed, 19 citations in OpenAlex.
- Reactive Oxygen Species-Mediated Autophagy by Ursolic Acid Inhibits Growth and Metastasis of Esophageal Cancer Cells.International journal of molecular sciences · 2020Article
- Undervalued criteria in the evaluation of multimodal trials for upper GI cancers.Cancer investigation · 2014Review
- Trimodal therapy in squamous cell carcinoma of the esophagus.European journal of medical research · 2011Article
- Curative treatment of oesophageal carcinoma: current options and future developments.Radiation oncology (London, England) · 2011Review
- [Esophageal squamous cell carcinoma: pre-operative combined radiochemotherapy from a surgical oncological viewpoint].Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen · 2009Review
- [Thoracoscopically assisted en bloc esophagectomy].Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen · 2009Article
- [Esophageal carcinoma. Results after esophageal resection].Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen · 2008Article
- [Esophageal carcinoma].Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen · 2007Article
- [Radiological imaging of the upper gastrointestinal tract. Part 1. The esophagus].Der Radiologe · 2006Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The fatalistic approach towards surgical therapy of esophageal squamous cell cancer has been replaced in recent years by a more differentiated view. This was triggered by the establishment of individualized therapeutic modalities based on tumor stage, tumor location, general patient status, and comorbidity. Despite advances in nonsurgical therapy of squamous cell esophageal cancer, esophagectomy remains the central therapeutic modality. Primary subtotal en-bloc esophagectomy with lymphadenectomy is the only curative option with a high likelihood of success for resectable tumors (uT1-3 categories) located below the level of the tracheal bifurcation and for early more proximal tumors. In patients with locally advanced tumors at or above the level of the tracheal bifurcation, surgical resection can still cure those who respond to neoadjuvant radiochemotherapy. Preoperative "conditioning" of risk patients, surgical safety strategies in risk situations, and standardization of both the operative procedure and the perioperative management have resulted in a marked reduction of the previously substantial postoperative mortality to below 3% in experienced centers. In our own experience of 900 esophagectomies for squamous cell esophageal cancer, the 5-year survival rate rose from about 20% to more than 50% in the last two decades. Esophagectomy thus has become a safe operation and remains the only therapeutic option offering cure for a substantial proportion of patients with squamous cell cancer of the esophagus.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.