Trial reportIntensive care medicine2005
Pressure-rate products and phase angles in children on minimal support ventilation and after extubation.
Trial report in Intensive care medicine, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 4 syntheses or guidelines pooled it, 52 citations in OpenAlex.
- Ventilation-Weaning Protocols in Children Admitted to Pediatric Intensive Care Units: Systematic Review of Randomized Trials.Pediatric pulmonology · 2025Pooled it
- Executive Summary: International Clinical Practice Guidelines for Pediatric Ventilator Liberation, A Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network Document.American journal of respiratory and critical care medicine · 2023Pooled it
- Recommendations for mechanical ventilation of critically ill children from the Paediatric Mechanical Ventilation Consensus Conference (PEMVECC).Intensive care medicine · 2017Guideline
- Weaning and extubation readiness in pediatric patients.Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies · 2009Pooled it
- Effect of pediatric ventilation weaning technique on work of breathing.Respiratory research · 2022Trial
- Positive end-expiratory pressure and pressure support in peripheral airways obstruction : work of breathing in intubated children.Intensive care medicine · 2007Trial
- Article
- Implementing the Pediatric Ventilator Liberation Guidelines Using the Most Current Evidence.Respiratory care · 2024Review
- Effort and work-of-breathing parameters strongly correlate with increased resistance in an animal model.Pediatric research · 2023Article
- Pressure support versus continuous positive airway pressure for predicting successful liberation from invasive ventilation in children: an open label, randomized non-inferiority trial.The Lancet regional health. Southeast Asia · 2023Article
- Reply to HavanAmerican journal of respiratory and critical care medicine · 2023Article
- Pediatric Ventilator Liberation: One-Hour Versus Two-Hour Spontaneous Breathing Trials in a Single Center.Respiratory care · 2023Article
- The Ideal Extubation Readiness Testing for the Pediatric Patient: Is There One?Respiratory care · 2023Article
- Pediatric Ventilation Liberation: A Survey of International Practice Among 555 Pediatric Intensivists.Critical care explorations · 2022Article
- Weaning from ventilation and extubation of children in critical care.BJA education · 2022Review
- Ventilator Liberation in the Pediatric ICU.Respiratory care · 2020Article
- Gasping at Straws: Role of Pressure Support During Spontaneous Breathing Trials in Children.Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies · 2020Article
- The effect of pressure support on imposed work of breathing during paediatric extubation readiness testing.Annals of intensive care · 2019Article
- A pilot study to assess short-term physiologic outcomes of transitioning infants with severe bronchopulmonary dysplasia from ICU to two subacute ventilators.Canadian journal of respiratory therapy : CJRT = Revue canadienne de la therapie respiratoire : RCTR · 2018Article
- Comparison of Effort of Breathing for Infants on Nasal Modes of Respiratory Support.The Journal of pediatrics · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo compare the pressure-rate products and phase angles of children during minimal support ventilation and after extubation. DESIGN AND
settingProspective, randomized single-center trial in a pediatric intensive care unit in a tertiary children's hospital.
methodsSeventeen endotracheally intubated, mechanically ventilated children were placed on T-piece, T-piece with heliox, continuous positive airway pressure, and pressure support in random order. Esophageal pressure swings, phase angles, respiratory mechanics, and physiological parameters were measured on these modes and after extubation. MEASUREMENTS AND
resultsPressure-rate product postextubation was significantly higher than on support modes. For each mode and after extubation they were: pressure support 198+/-31, continuous positive airway pressure 237+/-30, T-piece 323+/-47, T-piece/heliox 308+/-61, and extubation 378+/-43 cmH2O/min. Phase angles were significantly higher during T-piece ventilation than pressure support but not did not differ significantly from postextubation.
conclusionsAssessment of effort of breathing during even minimal mechanical ventilation may underestimate postextubation effort in children. Postextubation pressure-rate product and hence "effort of breathing" in children is best approximated by T-piece ventilation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.