ArticleIntensive care medicine2005
Activated protein C: do more survive?
Article in Intensive care medicine, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed.
- How the context of reception affects the meaning of RCT evidence.Health (London, England : 1997) · 2024Trial
- APCAP--activated protein C in acute pancreatitis: a double-blind randomized human pilot trial.Critical care (London, England) · 2010Trial
- Platelets at the intersection of inflammation and coagulation in the APC-mediated response to myocardial ischemia/reperfusion injury.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2024Review
- Activated protein C ameliorates Bacillus anthracis lethal toxin-induced lethal pathogenesis in rats.Journal of biomedical science · 2012Article
- Activated protein C in septic shock: a propensity-matched analysis.Critical care (London, England) · 2011Article
- Growing insights into the potential benefits and risks of activated protein C administration in sepsis: a review of preclinical and clinical studies.Biologics : targets & therapy · 2009Article
- Design, conduct, analysis and reporting of a multi-national placebo-controlled trial of activated protein C for persistent septic shock.Intensive care medicine · 2008Article
- How many patients with severe sepsis are needed to confirm the efficacy of drotrecogin alfa activated? A Bayesian design.Intensive care medicine · 2008Article
- Why are clinicians not embracing the results from pivotal clinical trials in severe sepsis? A bayesian analysis.PloS one · 2008Article
- Neuropeptide modulators of high mobility group box 1 secretion as potential therapeutic agents for severe sepsis.The American journal of pathology · 2008Article
- Medical guidelines and performance measures: the need to keep them free of industry influence.Mens sana monographs · 2008Article
- Drotrecogin alfa (activated) in severe sepsis: a systematic review and new cost-effectiveness analysis.BMC anesthesiology · 2007Article
- The effect of activated protein C on plasma cytokine levels in a porcine model of acute endotoxemia.Intensive care medicine · 2007Article
- [Endogenous anticoagulant therapy for sepsis. Success and failure].Der Internist · 2007Article
- Use of Drotrecogin alfa (activated) in Italian intensive care units: the results of a nationwide survey.Intensive care medicine · 2007Article
- The European Society of Intensive Care Medicine (ESICM) and the Surviving Sepsis Campaign (SSC).Intensive care medicine · 2007Article
- Clinical trials in severe sepsis with drotrecogin alfa (activated).Critical care (London, England) · 2007Review
- Activated protein C: cost-effective or costly?Critical care (London, England) · 2007Article
- Evaluation of drotrecogin alpha use in a Belgian university hospital.Pharmacy world & science : PWS · 2006Article
- Is the current management of severe sepsis and septic shock really evidence based?PLoS medicine · 2006Article
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Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
PubMed holds no abstract for this paper.
Indexed as
Identifiers
16228174What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.