ReviewHeart failure reviews2000
Extracellular matrix and growth factors during heart growth.
Review in Heart failure reviews, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
44 citing papers in PubMed, 113 citations in OpenAlex.
- A 3D Bioprinted dECM/CSCA/SA/NC Hybrid Scaffold for Myocardial Infarction Healing.Applied biochemistry and biotechnology · 2026Article
- Detergent-Based Decellularization for Anisotropic Cardiac-Specific Extracellular Matrix Scaffold Generation.Biomimetics (Basel, Switzerland) · 2023Article
- Mending a broken heart by biomimetic 3D printed natural biomaterial-based cardiac patches: a review.Frontiers in bioengineering and biotechnology · 2023Review
- Review
- Adult stem cell niches for tissue homeostasis.Journal of cellular physiology · 2022Review
- Basement Membrane Extracellular Matrix Proteins in Pulmonary Vascular and Right Ventricular Remodeling in Pulmonary Hypertension.American journal of respiratory cell and molecular biology · 2021Article
- Developmental Pathways of Cardiac Fibroblasts.Cold Spring Harbor perspectives in biology · 2020Review
- Bearing My Heart: The Role of Extracellular Matrix on Cardiac Development, Homeostasis, and Injury Response.Frontiers in cell and developmental biology · 2020Review
- Biodegradable Nanopolymers in Cardiac Tissue Engineering: From Concept Towards Nanomedicine.International journal of nanomedicine · 2020Review
- Extracellular Matrix in Regulation of Contractile System in Cardiomyocytes.International journal of molecular sciences · 2019Review
- Protein/polysaccharide-based scaffolds mimicking native extracellular matrix for cardiac tissue engineering applications.Journal of biomedical materials research. Part A · 2018Article
- Engineered Microenvironments for Maturation of Stem Cell Derived Cardiac Myocytes.Theranostics · 2018Review
- Regulation of the microenvironment for cardiac tissue engineering.Regenerative medicine · 2017Review
- Targeted inhibition of Focal Adhesion Kinase Attenuates Cardiac Fibrosis and Preserves Heart Function in Adverse Cardiac Remodeling.Scientific reports · 2017Article
- Xenogeneic Decellularized Scaffold: A Novel Platform for Ovary Regeneration.Tissue engineering. Part C, Methods · 2017Article
- Cardiac Progenitor Cells and the Interplay with Their Microenvironment.Stem cells international · 2017Review
- Naturally Engineered Maturation of Cardiomyocytes.Frontiers in cell and developmental biology · 2017Review
- Recommendations for genetic testing to reduce the incidence of anthracycline-induced cardiotoxicity.British journal of clinical pharmacology · 2016Review
- Biomaterial property-controlled stem cell fates for cardiac regeneration.Bioactive materials · 2016Review
- Prolonged Culture of Aligned Skeletal Myotubes on Micromolded Gelatin Hydrogels.Scientific reports · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The effects of growth factors on tissue remodeling and cell differentiation depend on the nature of the extracellular matrix, the type and organization of integrins, the activation of metalloproteinases and the presence of secreted proteins associated to the matrix. These interactions are actually poorly known in the cardiovascular system. We describe here: 1) the main components of extracellular matrix within the cardiovascular system; 2) the role of integrins in the transmission of growth signals; 3) the shift in the expression of the components of the extracellular matrix (fibronectin and collagens) and the stimulation of the synthesis of metalloproteinases during normal and hypertrophic growth of the myocardium; 4) the effects of growth factors, such as Angiotensin II, Fibroblast Growth Factors (FGF), Transforming Growth Factor-beta (TGF-beta), on the synthesis of proteins of the extracellular matrix in the heart.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.