ArticleMolecular and cellular biology2005
Dicer-dependent turnover of intergenic transcripts from the human beta-globin gene cluster.
Article in Molecular and cellular biology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed, 70 citations in OpenAlex.
- DICER1 and DGCR8 in thyroid tumorigenesis: miRNA biogenesis and histopathologic diversity.European thyroid journal · 2025Review
- Nuclear re-localization of Dicer in primary mouse embryonic fibroblast nuclei following DNA damage.PLoS genetics · 2018Article
- DICER1: A Key Player in Rheumatoid Arthritis, at the Crossroads of Cellular Stress, Innate Immunity, and Chronic Inflammation in Aging.Frontiers in immunology · 2018Review
- Nuclear phosphorylated Dicer processes double-stranded RNA in response to DNA damage.The Journal of cell biology · 2017Article
- HOXs and lincRNAs: Two sides of the same coin.Science advances · 2016Review
- Article
- Post-transcriptional gene silencing, transcriptional gene silencing and human immunodeficiency virus.World journal of virology · 2015Review
- The many faces of Dicer: the complexity of the mechanisms regulating Dicer gene expression and enzyme activities.Nucleic acids research · 2015Review
- Human nuclear Dicer restricts the deleterious accumulation of endogenous double-stranded RNA.Nature structural & molecular biology · 2014Article
- The double-stranded RNA binding domain of human Dicer functions as a nuclear localization signal.RNA (New York, N.Y.) · 2013Article
- Clinical and functional impact of TARBP2 over-expression in adrenocortical carcinoma.Endocrine-related cancer · 2013Article
- Convergent transcription induces transcriptional gene silencing in fission yeast and mammalian cells.Nature structural & molecular biology · 2012Article
- Hypermethylation of the gene LARP2 for noninvasive prenatal diagnosis of β-thalassemia based on DNA methylation profile.Molecular biology reports · 2012Article
- Nuclear pore complex protein mediated nuclear localization of dicer protein in human cells.PloS one · 2011Article
- Article
- Human tRNA-derived small RNAs in the global regulation of RNA silencing.RNA (New York, N.Y.) · 2010Article
- Maintenance of a constitutive heterochromatin domain in vertebrates by a Dicer-dependent mechanism.Nature cell biology · 2010Article
- Article
- Control of alternative splicing through siRNA-mediated transcriptional gene silencing.Nature structural & molecular biology · 2009Article
- Locus control region mediated regulation of adult beta-globin gene expression.Journal of cellular biochemistry · 2008Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The widespread occurrence of intergenic transcription in eukaryotes is increasingly evident. Intergenic transcription in the beta-globin gene cluster has been described in murine and human cells, and models for a role in gene and chromatin activation have been proposed. In this study, we analyze intergenic transcription and the chromatin state throughout the human beta-globin gene cluster and find that the data are not consistent with such activation-linked models. Thus, intergenic transcript levels correlate with neither chromatin activation nor globin gene expression. Instead, we find that intergenic transcripts of the beta-globin gene cluster are specifically upregulated in Dicer-deficient cells. This is accompanied by a shift towards more activated chromatin as indicated by changes in histone tail modifications. Our results strongly implicate RNA interference (RNAi)-related mechanisms in regulating intergenic transcription in the human beta-globin gene cluster and further suggest that RNAi-dependent chromatin silencing in vertebrates is not restricted to the centromeres.
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