ArticleMolecular and cellular biology2005
Global gene expression profiling reveals widespread yet distinctive translational responses to different eukaryotic translation initiation factor 2B-targeting stress pathways.
Article in Molecular and cellular biology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers.
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Who cites it
61 citing papers in PubMed, 97 citations in OpenAlex.
- Capturing Translation in Action with Protein Synthesis Profiling.bioRxiv : the preprint server for biology · 2025Article
- Construction of yeast microbial consortia for petroleum hydrocarbons degradation.Frontiers in bioengineering and biotechnology · 2024Article
- Post-transcriptional regulation during stress.FEMS yeast research · 2022Review
- Intrinsically disordered signaling proteins: Essential hub players in the control of stress responses in Saccharomyces cerevisiae.PloS one · 2022Article
- Psp2, a novel regulator of autophagy that promotes autophagy-related protein translation.Cell research · 2019Article
- Extensive post-transcriptional buffering of gene expression in the response to severe oxidative stress in baker's yeast.Scientific reports · 2019Article
- Translational regulation in response to stress in Saccharomyces cerevisiae.Yeast (Chichester, England) · 2019Review
- Multiplexing polysome profiling experiments to study translation in Escherichia coli.PloS one · 2019Article
- Archetypal transcriptional blocks underpin yeast gene regulation in response to changes in growth conditions.Scientific reports · 2018Article
- Dynamic changes in eIF4F-mRNA interactions revealed by global analyses of environmental stress responses.Genome biology · 2017Article
- Farnesol inhibits translation to limit growth and filamentation inMicrobial cell (Graz, Austria) · 2017Article
- Review
- Integrated multi-omics analyses reveal the pleiotropic nature of the control of gene expression by Puf3p.Scientific reports · 2015Article
- Butanol production in S. cerevisiae via a synthetic ABE pathway is enhanced by specific metabolic engineering and butanol resistance.Biotechnology for biofuels · 2015Article
- Delayed Ras/PKA signaling augments the unfolded protein response.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Co-ordination and divergence of cell-specific transcription and translation of genes in arabidopsis root cells.Annals of botany · 2014Article
- Chilling acclimation provides immunity to stress by altering regulatory networks and inducing genes with protective functions in cassava.BMC plant biology · 2014Article
- Puf3p induces translational repression of genes linked to oxidative stress.Nucleic acids research · 2014Article
- Genome-wide investigation of the role of the tRNA nuclear-cytoplasmic trafficking pathway in regulation of the yeast Saccharomyces cerevisiae transcriptome and proteome.Molecular and cellular biology · 2013Article
- The significance of translation regulation in the stress response.BMC genomics · 2013Article
1 more citing papers are in PubMed but not listed here.
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Authors and funding
10 authors at 2 institutions in 4 countries.
Funding
Abstract
Global inhibition of protein synthesis is a hallmark of many cellular stress conditions. Even though specific mRNAs defy this (e.g., yeast GCN4 and mammalian ATF4), the extent and variation of such resistance remain uncertain. In this study, we have identified yeast mRNAs that are translationally maintained following either amino acid depletion or fusel alcohol addition. Both stresses inhibit eukaryotic translation initiation factor 2B, but via different mechanisms. Using microarray analysis of polysome and monosome mRNA pools, we demonstrate that these stress conditions elicit widespread yet distinct translational reprogramming, identifying a fundamental role for translational control in the adaptation to environmental stress. These studies also highlight the complex interplay that exists between different stages in the gene expression pathway to allow specific preordained programs of proteome remodeling. For example, many ribosome biogenesis genes are coregulated at the transcriptional and translational levels following amino acid starvation. The transcriptional regulation of these genes has recently been connected to the regulation of cellular proliferation, and on the basis of our results, the translational control of these mRNAs should be factored into this equation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.