ArticleMolecular and cellular biology2005
Pairing between gypsy insulators facilitates the enhancer action in trans throughout the Drosophila genome.
Article in Molecular and cellular biology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
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45 citing papers in PubMed, 61 citations in OpenAlex.
- The homie insulator has sub-elements with different insulating and long-range pairing properties.Genetics · 2025Article
- ThebioRxiv : the preprint server for biology · 2025Article
- Impact of Interactions between Su(Hw)-Dependent Insulators on the Transvection Effect in Drosophila melanogaster.Doklady. Biochemistry and biophysics · 2024Article
- Transvection between nonallelic genomic positions in Drosophila.G3 (Bethesda, Md.) · 2024Article
- Topological screen identifies hundreds of Cp190- and CTCF-dependentScience advances · 2023Article
- Activating and repressing gene expression between chromosomes during stochastic fate specification.Cell reports · 2023Article
- The 3D genome landscape: Diverse chromosomal interactions and their functional implications.Frontiers in cell and developmental biology · 2022Review
- Multi-Scale Organization of theGenes · 2021Review
- Mechanisms of Enhancer-Promoter Interactions in Higher Eukaryotes.International journal of molecular sciences · 2021Review
- Position Effects Influence Transvection inGenetics · 2019Article
- Characterization of Button Loci that Promote Homologous Chromosome Pairing and Cell-Type-Specific Interchromosomal Gene Regulation.Developmental cell · 2019Article
- Highly structured homolog pairing reflects functional organization of the Drosophila genome.Nature communications · 2019Article
- Review
- The Role of Insulators in Transgene Transvection inGenetics · 2019Article
- Two modes of transvection at the eyes absent gene of Drosophila demonstrate plasticity in transcriptional regulatory interactions in cis and in trans.PLoS genetics · 2019Article
- Functional dissection of the developmentally restricted BEN domain chromatin boundary factor Insensitive.Epigenetics & chromatin · 2019Article
- Spermiogenesis and Male Fertility Require the Function of Suppressor of Hairy-Wing in Somatic Cyst Cells ofGenetics · 2018Article
- Visualization of Transvection in Living Drosophila Embryos.Molecular cell · 2018Article
- Article
- Transvection.Current biology : CB · 2017Article
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The Suppressor of the Hairy wing [Su(Hw)] binding region within the gypsy retrotransposon is the best known chromatin insulator in Drosophila melanogaster. According to previous data, two copies of the gypsy insulator inserted between an enhancer and a promoter neutralize each other's actions, which is indicative of an interaction between the protein complexes bound to the insulators. We have investigated the role of pairing between the gypsy insulators located on homologous chromosomes in trans interaction between yellow enhancers and a promoter. It has been shown that trans activation of the yellow promoter strongly depends on the site of the transposon insertion, which is evidence for a role of surrounding chromatin in homologous pairing. The presence of the gypsy insulators in both homologous chromosomes even at a distance of 9 kb downstream from the promoter dramatically improves the trans activation of yellow. Moreover, the gypsy insulators have proved to stabilize trans activation between distantly located enhancers and a promoter. These data suggest that gypsy insulator pairing is involved in communication between loci in the Drosophila genome.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.