ArticleJournal of neurology, neurosurgery, and psychiatry2005
Mild cognitive impairment in different functional domains and incident Alzheimer's disease.
Article in Journal of neurology, neurosurgery, and psychiatry, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 1 of them a synthesis that pooled it.
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Who cites it
46 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Cognitive and brain morphological deviations in middle-to-old aged autistic adults: A systematic review and meta-analysis.Neuroscience and biobehavioral reviews · 2024Pooled it
- Circulating Dkk1 and TRAIL Are Associated With Cognitive Decline in Community-Dwelling, Older Adults With Cognitive Concerns.The journals of gerontology. Series A, Biological sciences and medical sciences · 2018Trial
- Can cognitive enhancers reduce the risk of falls in older people with mild cognitive impairment? A protocol for a randomised controlled double blind trial.BMC neurology · 2009Trial
- Cognitive Function Mediates the Association Between Type 2 Diabetes and Physical Performance Decline in Older Adults: A Cross-Sectional Study.Healthcare (Basel, Switzerland) · 2026Article
- Is memory in older adulthood influenced by changes in air pollution over the previous decade?: Examining concurrent trajectories in ambient PMEnvironmental epidemiology (Philadelphia, Pa.) · 2026Article
- Optimizing electrode configurations for EEG mild cognitive impairment detection.Scientific reports · 2025Article
- Predictors of cognitive change in cognitively healthy older women in Panama: the PARI-HD study.Frontiers in global women's health · 2024Article
- Retention and impairment of neurocognitive functions in mild cognitive impairment and Alzheimer's disease with a comprehensive neuropsychological test.Neuropsychopharmacology reports · 2022Article
- Self Assessment Memory Scale (SAMS), a new simple method for evaluating memory function.Frontiers in aging neuroscience · 2022Article
- The Clinical Course of Early and Late Mild Cognitive Impairment.Frontiers in neurology · 2022Article
- Article
- Optimizing differential identifiability improves connectome predictive modeling of cognitive deficits from functional connectivity in Alzheimer's disease.Human brain mapping · 2021Article
- Memory and Personality Development in Adulthood: Evidence From Four Longitudinal Studies.The journals of gerontology. Series B, Psychological sciences and social sciences · 2021Article
- Amyloid-Beta Influences MemoryFrontiers in aging neuroscience · 2021Article
- Fragile X Gray Zone Alleles Are Associated With Signs of Parkinsonism and Earlier Death.Movement disorders : official journal of the Movement Disorder Society · 2020Article
- Personality and memory performance over twenty years: Findings from three prospective studies.Journal of psychosomatic research · 2020Article
- Beta-amyloid pathology in human brain microvessel extracts from the parietal cortex: relation with cerebral amyloid angiopathy and Alzheimer's disease.Acta neuropathologica · 2019Article
- Myostatin Is Associated With Cognitive Decline in an Animal Model of Alzheimer's Disease.Molecular neurobiology · 2019Article
- Impact of multiple pathologies on the threshold for clinically overt dementia.Acta neuropathologica · 2017Review
- Early Functional Limitations in Cognitively Normal Older Adults Predict Diagnostic Conversion to Mild Cognitive Impairment.Journal of the American Geriatrics Society · 2017Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
backgroundLittle is known about factors that predict transition from mild cognitive impairment to Alzheimer's disease (AD).
objectiveTo examine the relation of impairment in different cognitive systems to risk of developing AD in persons with mild cognitive impairment.
methodsParticipants are 218 older Catholic clergy members from the Religious Orders Study. At baseline, they met criteria for mild cognitive impairment based on a uniform clinical evaluation that included detailed cognitive testing. Evaluations were repeated annually for up to 10 years. Analyses were controlled for age, sex, and education.
resultsEighty two persons (37.6%) developed AD. In separate analyses, episodic memory, semantic memory, working memory, and perceptual speed, but not visuospatial ability, were associated with risk of AD, but when analysed together only episodic memory and perceptual speed were associated with AD incidence, with the effect for episodic memory especially strong. Overall, those with impaired episodic memory were more than twice as likely to develop AD as those with impairment in other cognitive domains (relative risk (RR) = 2.45; 95% confidence interval (CI): 1.53 to 3.92), and they experienced more rapid cognitive decline. Lower episodic memory performance was associated with increased risk of AD throughout the observation period, whereas impairment in other cognitive domains was primarily associated with risk during the following year but not thereafter.
conclusionAmong persons with mild cognitive impairment, episodic memory impairment is associated with a substantial and persistent elevation in risk of developing AD compared to impairment in other cognitive systems.
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