ArticleProceedings of the National Academy of Sciences of the United States of America2005
Plasmodium vivax: recent world expansion and genetic identity to Plasmodium simium.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed.
- Genomic Insights Into Host Shifts BetweenEvolutionary applications · 2026Article
- Anopheles (Kerteszia) cruzii infected by Plasmodium in the Atlantic Forest indicates that the malaria transmission cycle is maintained even after howler monkeys' population decline.Parasitology research · 2022Article
- Evolutionary history of Plasmodium vivax and Plasmodium simium in the Americas.Malaria journal · 2022Review
- Review
- Plasmodium simium: Population Genomics Reveals the Origin of a Reverse Zoonosis.The Journal of infectious diseases · 2021Article
- Plasmodium vivax pre-erythrocytic vaccines.Parasitology international · 2021Review
- A universal vaccine candidate against Plasmodium vivax malaria confers protective immunity against the three PvCSP alleles.Scientific reports · 2021Article
- Progress towards the development of aExpert review of vaccines · 2021Review
- A mathematical model for zoonotic transmission of malaria in the Atlantic Forest: Exploring the effects of variations in vector abundance and acrodendrophily.PLoS neglected tropical diseases · 2021Article
- Atlantic Forest Malaria: A Review of More than 20 Years of Epidemiological Investigation.Microorganisms · 2021Review
- Reemergence of human malaria in Atlantic Forest of Rio Grande do Sul, Brazil.Memorias do Instituto Oswaldo Cruz · 2021Article
- Article
- Genotyping and Phylogenetic Analysis ofIranian journal of public health · 2020Article
- Plasmodium vivax Malaria Viewed through the Lens of an Eradicated European Strain.Molecular biology and evolution · 2020Article
- Parasite-Host Interaction and Pathophysiology Studies of the Human Relapsing MalariasFrontiers in cellular and infection microbiology · 2020Review
- Defining the ecological and evolutionary drivers of Plasmodium knowlesi transmission within a multi-scale framework.Malaria journal · 2019Review
- Chimeric Plasmodium falciparum parasites expressing Plasmodium vivax circumsporozoite protein fail to produce salivary gland sporozoites.Malaria journal · 2018Article
- Malaria Elimination: Time to Target All Species.The American journal of tropical medicine and hygiene · 2018Review
- Assessment of asymptomatic Plasmodium spp. infection by detection of parasite DNA in residents of an extra-Amazonian region of Brazil.Malaria journal · 2018Article
- Human migration and the spread of malaria parasites to the New World.Scientific reports · 2018Article
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Plasmodium vivax causes the most geographically widespread human malaria, accounting annually for 70-80 million clinical cases throughout the tropical and subtropical regions of the world's continents. We have analyzed the DNA sequences of the Csp (circumsporozoite protein) gene in 24 geographically representative strains of P. vivax and 2 of P. simium, which parasitizes several species of New World monkeys. The Csp sequences are of two types, VK210 and VK247, which differ by three diagnostic amino acid replacements, one in each of the 5' and 3' terminal regions [5' nonrepeat (NR) and 3' NR] of the gene and in an insertion sequence that precedes the 3' NR region. The central region of the gene consists of approximately 38 repetitive "motifs," which are alternatively four and five amino acids long, which also are diagnostically different between the VK210 and VK247 types. There are very few synonymous substitutions within and between the two types of strains, which we hypothesize reflects that the worldwide spread of P. vivax is very recent. The two P. simium Csp sequences belong one to each of the two VK types and are genetically indistinguishable from the corresponding P. vivax strains, suggesting that at least two host transfers have occurred between humans and New World monkeys. We exclude as unlikely the possibility that the two types of sequences could have independently arisen in humans and platyrrhines by natural selection. There are reasons favoring each of the two possible directions of host transfer between humans and monkeys.
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