Evidence map›Paper›PMID 16224455›Full record

ReviewNature reviews. Drug discovery2005

Chemokines: integrators of pain and inflammation.

Fletcher A White, Sonia K Bhangoo, Richard J Miller

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Nature reviews. Drug discovery, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 138 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
138citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

138 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  6. Journal of pain research · 2026
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78 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Fletcher A WhiteDepartment of Cell Biology, Neurobiology and Anatomy, Stritch School of Medicine, Loyola University, Maywood, Illinois 60153, USA.
Sonia K Bhangoo
Richard J Miller

Funding

HIV-1-Related Peripheral Sensory NeuropathyR01NS043095 · NINDS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI MILLER, RICHARD J · 2002 to 2011
$3.6M
Mechanisms of Neuropathic Pain in Demylenated NervesR01NS049136 · NINDS · LOYOLA UNIVERSITY CHICAGO · PI WHITE, FLETCHER A · 2006 to 2010
$1.3M
NINDS NIH HHS R01 NS043095NINDS NIH HHS R01 NS049136
6 · The paper itself

Abstract

Chronic (neuropathic) pain is one of the most widespread and intractable of human complaints, as well as being one of the most difficult syndromes to treat successfully with drugs or surgery. The development of new therapeutic approaches to the treatment of painful neuropathies requires a better understanding of the mechanisms that underlie the development of these chronic pain syndromes. It is clear that inflammatory responses often accompany the development of neuropathic pain, and here we discuss the idea that chemokines might be key to integrating the development of pain and inflammation and could furnish new leads in the search for effective analgesic agents for the treatment of painful neuropathies.

Indexed as

ChemokinesHumansInflammationPainChemokines

Identifiers

PMID16224455
PMCPMC2792904

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.