ArticleHuman heredity2005
SimPed: a simulation program to generate haplotype and genotype data for pedigree structures.
Article in Human heredity, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 69 citations in OpenAlex.
- Estimation of Jacquard's genetic identity coefficients with bi-allelic variants by constrained least-squares.Heredity · 2025Article
- Using genomic prediction to detect microevolutionary change of a quantitative trait.Proceedings. Biological sciences · 2022Article
- FamEvent: An R Package for Generating and Modeling Time-to-Event Data in Family Designs.Journal of statistical software · 2021Article
- A Family-Based Rare Haplotype Association Method for Quantitative Traits.Human heredity · 2018Article
- An Efficient Test for Gene-Environment Interaction in Generalized Linear Mixed Models with Family Data.International journal of environmental research and public health · 2017Article
- Increased Power for Detection of Parent-of-Origin Effects via the Use of Haplotype Estimation.American journal of human genetics · 2015Article
- Reproducible simulations of realistic samples for next-generation sequencing studies using Variant Simulation Tools.Genetic epidemiology · 2015Article
- Genetic data simulators and their applications: an overview.Genetic epidemiology · 2015Article
- Deciphering the fine-structure of tribal admixture in the Bedouin population using genomic data.Heredity · 2014Article
- PREMIM and EMIM: tools for estimation of maternal, imprinting and interaction effects using multinomial modelling.BMC bioinformatics · 2012Article
- Obtaining accurate p values from a dense SNP linkage scan.Human heredity · 2012Article
- Integration of SNP genotyping confidence scores in IBD inference.Bioinformatics (Oxford, England) · 2011Article
- Coordinated conditional simulation with SLINK and SUP of many markers linked or associated to a trait in large pedigrees.Human heredity · 2011Article
- Potentials and limits of pairwise kinship analysis using autosomal short tandem repeat loci.International journal of legal medicine · 2010Article
- A novel approach to simulate gene-environment interactions in complex diseases.BMC bioinformatics · 2010Article
- Detecting genome-wide haplotype polymorphism by combined use of Mendelian constraints and local population structure.Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing · 2010Article
- An almost linear time algorithm for a general haplotype solution on tree pedigrees with no recombination and its extensions.Journal of bioinformatics and computational biology · 2009Article
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- Most parsimonious haplotype allele sharing determination.BMC bioinformatics · 2009Article
- GABRG1 and GABRA2 as independent predictors for alcoholism in two populations.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 2 countries.
Funding
Abstract
With the widespread availability of SNP genotype data, there is great interest in analyzing pedigree haplotype data. Intermarker linkage disequilibrium for microsatellite markers is usually low due to their physical distance; however, for dense maps of SNP markers, there can be strong linkage disequilibrium between marker loci. Linkage analysis (parametric and nonparametric) and family-based association studies are currently being carried out using dense maps of SNP marker loci. Monte Carlo methods are often used for both linkage and association studies; however, to date there are no programs available which can generate haplotype and/or genotype data consisting of a large number of loci for pedigree structures. SimPed is a program that quickly generates haplotype and/or genotype data for pedigrees of virtually any size and complexity. Marker data either in linkage disequilibrium or equilibrium can be generated for greater than 20,000 diallelic or multiallelic marker loci. Haplotypes and/or genotypes are generated for pedigree structures using specified genetic map distances and haplotype and/or allele frequencies. The simulated data generated by SimPed is useful for a variety of purposes, including evaluating methods that estimate haplotype frequencies for pedigree data, evaluating type I error due to intermarker linkage disequilibrium and estimating empirical p values for linkage and family-based association studies.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.