ArticleBlood2006
Arrested natural killer cell development associated with transgene insertion into the Atf2 locus.
Article in Blood, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 25 citations in OpenAlex.
- CD127International journal of molecular sciences · 2026Article
- Immunoreceptor tyrosine-based inhibitory motif-dependent functions of an MHC class I-specific NK cell receptor.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Differential Role of Hematopoietic and Nonhematopoietic Cell Types in the Regulation of NK Cell Tolerance and Responsiveness.Journal of immunology (Baltimore, Md. : 1950) · 2016Article
- Pro-inflammatory role of natural killer cells in the development of allergic airway disease.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2014Article
- NK cell maturation and function in C57BL/6 mice are altered by caloric restriction.Journal of immunology (Baltimore, Md. : 1950) · 2013Article
- Article
- miR-150 regulates the development of NK and iNKT cells.The Journal of experimental medicine · 2011Article
- The role of natural killer cells in sepsis.Journal of biomedicine & biotechnology · 2011Review
- Natural killer cells require selectins for suppression of subcutaneous tumors.Cancer research · 2009Article
- Distal-less homeobox transcription factors regulate development and maturation of natural killer cells.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
- Article
- Induction of natural killer cell responses by ectromelia virus controls infection.Journal of virology · 2007Article
- Identification, activation, and selective in vivo ablation of mouse NK cells via NKp46.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors at 1 institution in 1 country.
Funding
Abstract
Natural killer (NK) cell development in the bone marrow is not fully understood. Following lineage commitment, these cells appear to advance through a series of developmental stages that are beginning to be characterized. We previously reported a selective deficiency of NK cells in a C57BL/6 mouse with a transgenic construct consisting of the cDNA for the Ly49A major histocompatibility complex (MHC) class 1-specific inhibitory receptor driven by the granzyme A gene. This mouse has few NK cells in peripheral tissues with relative preservation of other immune cells, including T and B cells. Herein we demonstrate that these mice have an accumulation of NK cells with an immature phenotype in the bone marrow, consistent with a block at a previously proposed stage in normal NK-cell development. The phenotype is associated with transgenic insertion into Atf2, the gene for the basic leucine zipper (bZIP) transcription factor family member ATF-2. Although analysis of Atf2-null NK cells shows no defect, the transgenic mice express abnormal truncated Atf2 transcripts that may mediate a repressor effect because ATF2 can heterodimerize with other bZIP molecules. The defect is cell intrinsic, suggesting that certain bZIP molecules play significant roles in NK-cell development.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.