ArticleThe Journal of physiology2005
Nitric oxide blunts myogenic autoregulation in rat renal but not skeletal muscle circulation via tubuloglomerular feedback.
Article in The Journal of physiology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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21 citing papers in PubMed, 66 citations in OpenAlex.
- Knockout of Sirtuin 3 in endothelial cells impairs endothelial-dependent relaxation and myogenic response in mice.Physiological reports · 2024Article
- Resting-state MRI reveals spontaneous physiological fluctuations in the kidney and tracks diabetic nephropathy in rats.American journal of physiology. Renal physiology · 2024Article
- Nitric oxide signalling in kidney regulation and cardiometabolic health.Nature reviews. Nephrology · 2021Review
- Renal autoregulation and blood pressure management in circulatory shock.Critical care (London, England) · 2018Review
- Concerted regulation of renal plasma flow and glomerular filtration rate by renal dopamine and NOS I in rats on high salt intake.Physiological reports · 2017Article
- Modulation of the myogenic mechanism: concordant effects of NO synthesis inhibition and O2- dismutation on renal autoregulation in the time and frequency domains.American journal of physiology. Renal physiology · 2016Article
- Glomerulosclerosis in the diet-induced obesity model correlates with sensitivity to nitric oxide inhibition but not glomerular hyperfiltration or hypertrophy.American journal of physiology. Renal physiology · 2015Article
- Mathematical modeling of renal hemodynamics in physiology and pathophysiology.Mathematical biosciences · 2015Article
- Recent advances in renal hemodynamics: insights from bench experiments and computer simulations.American journal of physiology. Renal physiology · 2015Review
- Renal autoregulation in health and disease.Physiological reviews · 2015Review
- Large BP-dependent and -independent differences in susceptibility to nephropathy after nitric oxide inhibition in Sprague-Dawley rats from two major suppliers.American journal of physiology. Renal physiology · 2012Article
- Superoxide modulates myogenic contractions of mouse afferent arterioles.Hypertension (Dallas, Tex. : 1979) · 2011Article
- Modulation of the myogenic response in renal blood flow autoregulation by NO depends on endothelial nitric oxide synthase (eNOS), but not neuronal or inducible NOS.The Journal of physiology · 2011Article
- Connecting tubule glomerular feedback antagonizes tubuloglomerular feedback in vivo.American journal of physiology. Renal physiology · 2010Article
- Glomerular hyperfiltration in adult sickle cell anemia: a frequent hemolysis associated feature.Clinical journal of the American Society of Nephrology : CJASN · 2010Article
- Protective importance of the myogenic response in the renal circulation.Hypertension (Dallas, Tex. : 1979) · 2009Review
- Connexin 40 mediates the tubuloglomerular feedback contribution to renal blood flow autoregulation.Journal of the American Society of Nephrology : JASN · 2009Article
- Possible mediators of connecting tubule glomerular feedback.Hypertension (Dallas, Tex. : 1979) · 2009Article
- Continuously measured renal blood flow does not increase in diabetes if nitric oxide synthesis is blocked.American journal of physiology. Renal physiology · 2008Article
- Renal autoregulation: new perspectives regarding the protective and regulatory roles of the underlying mechanisms.American journal of physiology. Regulatory, integrative and comparative physiology · 2006Review
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Abstract
This rat renal blood flow (RBF) study quantified the impact of nitric oxide synthase (NOS) inhibition on the myogenic response and the balance of autoregulatory mechanisms in the time domain following a 20 mmHg-step increase or decrease in renal arterial pressure (RAP). When RAP was increased, the myogenic component of renal vascular resistance (RVR) rapidly rose within the initial 7-10 s, exhibiting an approximately 5 s time constant and providing approximately 36% of perfect autoregulation. A secondary rise between 10 and 40 s brought RVR to 95% total autoregulatory efficiency, reflecting tubuloglomerular feedback (TGF) and possibly one or two additional mechanisms. The kinetics were similar after the RAP decrease. Inhibition of NOS (by l-NAME) increased RAP, enhanced the strength (79% autoregulation) and doubled the speed of the myogenic response, and promoted the emergence of RVR oscillations ( approximately 0.2 Hz); the strength (52%) was lower at control RAP. An equi-pressor dose of angiotensin II had no effect on myogenic or total autoregulation. Inhibition of TGF (by furosemide) abolished the l-NAME effect on the myogenic response. RVR responses during furosemide treatment, assuming complete inhibition of TGF, suggest a third mechanism that contributes 10-20% and is independent of TGF, slower than the myogenic response, and abolished by NOS inhibition. The hindlimb circulation displayed a solitary myogenic response similar to the kidney (35% autoregulation) that was not enhanced by l-NAME. We conclude that NO normally restrains the strength and speed of the myogenic response in RBF but not hindlimb autoregulation, an action dependent on TGF, thereby allowing more and slow RAP fluctuations to reach glomerular capillaries.
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