ArticleNeurobiology of aging2006
Genetic variation in the choline acetyltransferase (CHAT) gene may be associated with the risk of Alzheimer's disease.
Article in Neurobiology of aging, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 4 of them syntheses that pooled it.
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Who cites it
14 citing papers in PubMed, 4 syntheses or guidelines pooled it, 42 citations in OpenAlex.
- Polymorphisms of CHAT but not TFAM or VR22 are Associated with Alzheimer Disease Risk.Medical science monitor : international medical journal of experimental and clinical research · 2016Pooled it
- Genetic Association of CHAT rs3810950 and rs2177369 Polymorphisms with the Risk of Alzheimer's Disease: A Meta-Analysis.BioMed research international · 2016Pooled it
- Pooled it
- Meta-analyses of 8 polymorphisms associated with the risk of the Alzheimer's disease.PloS one · 2013Pooled it
- Heterologous expressing melittin in a probiotic yeast to evaluate its function for promoting NSC-34 regeneration.Applied microbiology and biotechnology · 2024Article
- Mutations in SORL1 and MTHFDL1 possibly contribute to the development of Alzheimer's disease in a multigenerational Colombian Family.PloS one · 2022Article
- Cholinergic Modulation of the Immune System in Neuroinflammatory Diseases.Diseases (Basel, Switzerland) · 2021Review
- Statistical analysis of spatial expression patterns for spatially resolved transcriptomic studies.Nature methods · 2020Article
- Donepezil improves the cognitive impairment in a tree shrew model of Alzheimer's disease induced by amyloid-βMetabolic brain disease · 2018Article
- CHAT gene polymorphism rs3810950 is associated with the risk of Alzheimer's disease in the Czech population.Journal of biomedical science · 2018Article
- Cholinergic Pathway SNPs and Postural Control in 477 Older Adults.Frontiers in aging neuroscience · 2018Article
- Genetic variants in the choline acetyltransferase (ChAT) gene are modestly associated with normal cognitive function in the elderly.Genes, brain, and behavior · 2011Article
- Cholinergic deficiency hypothesis in delirium: a synthesis of current evidence.The journals of gerontology. Series A, Biological sciences and medical sciences · 2008Review
- Lack of association of two chromosome 10q24 SNPs with Alzheimer's disease.Neuroscience letters · 2006Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Several independent linkage studies have mapped a broad susceptibility region for Alzheimer's disease (AD) on the long arm of chromosome 10. There are several biological candidate genes in this region, including choline acetyltransferase (CHAT). A number of studies have examined the role of CHAT genetic variants with AD risk and age-at-onset (AAO), but the results are equivocal. We examined the association of three Single Nucleotide Polymorphisms (SNPs) in the CHAT gene in 1001 white sporadic late-onset AD (LOAD) cases and 708 white controls. We also examined the role of these three SNP with quantitative traits of AD including AAO, disease duration, and Mini-Mental State Examination (MMSE) score. We observed both allelic and genotypic associations of the intron 9 SNP with AD risk in the total sample (p = 0.029 for genotype and p = 0.028 for allele frequency differences) as well as among non-APOE*4 carriers (p = 0.007 for genotype and p = 0.006 for allele frequency differences). Three-site haplotype analysis confirmed that haplotypes determined by the intron 9 SNP were associated with either risk (p = 0.0009) or protective (p = 0.0082) effects among non-APOE*4 carriers. The three CHAT SNPs also showed a modest association with MMSE score. Our data suggest that genetic variation in the CHAT gene may be associated with AD risk and quantitative traits related to AD.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.