ArticleExperimental cell research2005
Differentiation of murine embryonic stem cells induces progesterone receptor gene expression.
Article in Experimental cell research, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.
- Molecular Basis of Müllerian Agenesis Causing Congenital Uterine Factor Infertility-A Systematic Review.International journal of molecular sciences · 2023Pooled it
- Article
- Primordial germ cells can be differentiated by retinoic acid and progesterone induction from embryonic stem cells.Journal of biosciences · 2021Article
- Developing a deeper insight into reproductive biomarkers.Clinical and experimental reproductive medicine · 2017Review
- Recent advances in the molecular mechanisms of Mayer-Rokitansky-Küster-Hauser syndrome.Biomedical reports · 2017Article
- Investigating core genetic-and-epigenetic cell cycle networks for stemness and carcinogenic mechanisms, and cancer drug design using big database mining and genome-wide next-generation sequencing data.Cell cycle (Georgetown, Tex.) · 2016Article
- The Androgen Receptor Bridges Stem Cell-Associated Signaling Nodes in Prostate Stem Cells.Stem cells international · 2016Review
- Androgen receptor increases CD133 expression and progenitor-like population that associate with cisplatin resistance in endometrial cancer cell line.Reproductive sciences (Thousand Oaks, Calif.) · 2014Article
- Biomarker genes for detecting estrogenic activity of endocrine disruptors via estrogen receptors.International journal of environmental research and public health · 2012Review
- A combination of transcriptome and methylation analyses reveals embryologically-relevant candidate genes in MRKH patients.Orphanet journal of rare diseases · 2011Article
- The pregnancy hormones human chorionic gonadotropin and progesterone induce human embryonic stem cell proliferation and differentiation into neuroectodermal rosettes.Stem cell research & therapy · 2010Article
- LIF removal increases CRABPI and CRABPII transcripts in embryonic stem cells cultured in retinol or 4-oxoretinol.Molecular and cellular endocrinology · 2008Article
- Changes in the content of estrogen alpha and progesterone receptors during differentiation of mouse embryonic stem cells to dopamine neurons.Brain research bulletin · 2007Article
- Nuclear Receptors in Regulation of Mouse ES Cell Pluripotency and Differentiation.PPAR research · 2007Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
The role of steroid hormone receptors in very early embryonic development remains unknown. Clearly, expression during organogenesis is important for tissue-specific development. However, progesterone receptor (PR) and estrogen receptors (ERalpha, ERbeta) are expressed during early development through the blastocyst stage in mice and other species, and yet are not essential for embryonic viability. We have utilized the mouse embryonic stem (mES) cell model to investigate the regulated expression of these receptors during differentiation. Surprisingly, one of the earliest changes in gene expression in response to a differentiation signal observed is PR gene induction. It parallels the time course of expression for the patterning genes Hoxb1 and Hoxa5. Unexpectedly, PR gene expression is not regulated in an estrogen-dependent manner by endogenous ERs or by transiently overexpressed ERalpha. Our results suggest a potentially novel mechanism of PR gene regulation within mES cells compared to adult tissues and the possibility of unique targets of PR action during early mES cell differentiation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.