ArticleWorld journal of gastroenterology2005
Hepatic fibrosis in biliary-obstructed rats is prevented by Ginkgo biloba treatment.
Article in World journal of gastroenterology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 33 citations in OpenAlex.
- Dodder (Northern clinics of Istanbul · 2024Article
- Anti-fibrotic effect of Holothuria arenicola extract against bile duct ligation in rats.BMC complementary and alternative medicine · 2015Article
- Liver fibrosis and mechanisms of the protective action of medicinal plants targeting inflammation and the immune response.International journal of inflammation · 2015Review
- Protective mechanisms of medicinal plants targeting hepatic stellate cell activation and extracellular matrix deposition in liver fibrosis.Chinese medicine · 2014Article
- Attenuating effect of Ginkgo biloba leaves extract on liver fibrosis induced by thioacetamide in mice.Journal of biomedicine & biotechnology · 2012Article
- Effect of the nucleotides CMP and UMP on exhaustion in exercise rats.Journal of physiology and biochemistry · 2008Article
- Effect of ATRA on contents of liver retinoids, oxidative stress and hepatic injury in rat model of extrahepatic cholestasis.Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban · 2007Article
- Enhancement of pituitary adenoma cell invasion and adhesion is mediated by discoidin domain receptor-1.Journal of neuro-oncology · 2007Article
- Erdosteine treatment attenuates oxidative stress and fibrosis in experimental biliary obstruction.Pediatric surgery international · 2007Article
- Ginkgo biloba extract (EGb 761) attenuates lung injury induced by intestinal ischemia/reperfusion in rats: roles of oxidative stress and nitric oxide.World journal of gastroenterology · 2007Article
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Authors and funding
5 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
aimTo assess the antioxidant and antifibrotic effects of long-term Ginkgo biloba administration on liver fibrosis induced by biliary obstruction in rats.
methodsLiver fibrosis was induced in male Wistar albino rats by bile duct ligation and scission (BDL). Ginkgo biloba extract (EGb 761, 50 mg/kg.per d) or saline was administered for 28 d. At the end of the treatment period, all rats were killed. Serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), and lactate dehydrogenase (LDH) levels were determined to assess liver functions and tissue damage, respectively. Tumor necrosis factor-alpha (TNF-alpha) was also assayed in serum samples. Liver tissues were taken for determination of the hepatic malondialdehyde (MDA) and glutathione (GSH) levels, myeloperoxidase (MPO) activity and collagen content. Production of reactive oxidants was monitored by chemiluminescence (CL) assay. Serum AST, ALT, LDH, and TNF-alpha levels were elevated in the BDL group as compared to control group and were significantly decreased by EGb treatment.
resultsHepatic GSH level, depressed by BDL, was elevated back to control level in EGb-treated BDL group. Increase in tissue MDA level, MPO activity and collagen content due to BDL were also attenuated by EGb treatment. Furthermore, luminol and lucigenin CL values in BDL group increased dramatically compared to control and reduced by EGb treatment.
conclusionOur results suggest that Ginkgo biloba protects the liver from oxidative damage following BDL in rats. This effect possibly involves the inhibition of neutrophil infiltration and lipid peroxidation; thus, restoration of oxidant and antioxidant status in the tissue.
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