ArticleWorld journal of surgery2005
Effect of neostigmine on organ injury in murine endotoxemia: missing facts about the cholinergic antiinflammatory pathway.
Article in World journal of surgery, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Sugammadex vs neostigmine in post-anesthesia recovery: A systematic review and meta-analysis.Biomolecules & biomedicine · 2025Pooled it
- The Hepatic Nerves Regulated Inflammatory Effect in the Process of Liver Injury: Is Nerve the Key Treating Target for Liver Inflammation?Inflammation · 2023Review
- Effects of coenzyme Q10 in a propofol infusion syndrome model of rabbits.Asian biomedicine : research, reviews and news · 2023Article
- Neuroimmune nexus in the pathophysiology and therapy of inflammatory disorders: Role of α7 nicotinic acetylcholine receptors.Pharmacological research · 2023Review
- New advances in clinical application of neostigmine: no longer focusing solely on increasing skeletal muscle strength.Frontiers in pharmacology · 2023Review
- Treating disorders across the lifespan by modulating cholinergic signaling with galantamine.Journal of neurochemistry · 2021Review
- Autonomic and cholinergic mechanisms mediating cardiovascular and temperature effects of donepezil in conscious mice.American journal of physiology. Regulatory, integrative and comparative physiology · 2021Article
- The Cholinergic Drug Pyridostigmine Alleviates Inflammation During LPS-Induced Acute Respiratory Distress Syndrome.Frontiers in pharmacology · 2021Article
- In Vivo Effects of Neostigmine and Physostigmine on Neutrophil Functions and Evaluation of Acetylcholinesterase and Butyrylcholinesterase as Inflammatory Markers during Experimental Sepsis in Rats.Mediators of inflammation · 2019Article
- Vagus nerve cholinergic circuitry to the liver and the gastrointestinal tract in the neuroimmune communicatome.American journal of physiology. Gastrointestinal and liver physiology · 2018Review
- Therapeutic effects of physostigmine during systemic inflammation.Journal of inflammation research · 2018Article
- Increase in cholinergic modulation with pyridostigmine induces anti-inflammatory cell recruitment soon after acute myocardial infarction in rats.American journal of physiology. Regulatory, integrative and comparative physiology · 2016Article
- Neural circuitry and immunity.Immunologic research · 2015Review
- Postponed effect of neostigmine on oxidative homeostasis.Interdisciplinary toxicology · 2014Article
- Effects of combined anisodamine and neostigmine treatment on the inflammatory response and liver regeneration of obstructive jaundice rats after hepatectomy.BioMed research international · 2014Article
- Presymptomatic treatment with acetylcholinesterase antisense oligonucleotides prolongs survival in ALS (G93A-SOD1) mice.BioMed research international · 2013Article
- Rethinking inflammation: neural circuits in the regulation of immunity.Immunological reviews · 2012Review
- Effects of early administration of a novel anticholinergic drug on acute respiratory distress syndrome induced by sepsis.Medical science monitor : international medical journal of experimental and clinical research · 2011Article
- Cholinergic stimulation of the immune system protects against lethal infection by Salmonella enterica serovar Typhimurium.Immunology · 2010Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Electrical and pharmacologic stimulation of the efferent cholinergic antiinflammatory pathway suppress the systemic inflammatory response and can prevent lethal endotoxemia. Neostigmine, a cholinergic agent, has not been tested to determine if it can prevent histopathologic organ injury in endotoxemia. In the present study, the effects of neostigmine treatment on the histopathologic organ injury inflicted by Escherichia coli endotoxin in a mouse model of septic shock was investigated. Endotoxemia in mice caused weight loss and increased spleen, liver, and lung weight. When the organs were examined for histopathologic injury, endotoxemia increased interstitial inflammation in the lungs, liver injury, and organ injury in general terms; neostigmine, at a dose of 0.1 mg/kg, failed to attenuate these effects. Although the simultaneous administration of neostigmine at a dose of 0.3 mg/kg and endotoxin decreased interstitial inflammation in the lungs, vacuolar degeneration in the liver, and total liver injury, mortality was increased with this dose in the presence of endotoxemia. We conclude that neostigmine at a dose of 0.1 mg/kg was not protective against histopathologic organ injury in mice with endotoxemia, and a higher dose (0.3 mg/kg) was not tolerated probably owing to nonspecific parasympathetic action including cardiovascular effects. Further studies are required to determine the contribution of sites in the cholinergic antiinflammatory pathway.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.