ReviewProceedings of the American Thoracic Society2005
Nitric oxide and zinc homeostasis in acute lung injury.
Review in Proceedings of the American Thoracic Society, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 43 citations in OpenAlex.
- Synchrotron-based X-ray fluorescence microscopy reveals accumulation of polymyxins in single human alveolar epithelial cells.Antimicrobial agents and chemotherapy · 2023Article
- Friend or Foe? The Roles of Antioxidants in Acute Lung Injury.Antioxidants (Basel, Switzerland) · 2021Review
- The mechanism of nicotinamide on reducing acute lung injury by inhibiting MAPK and NF-κB signal pathway.Molecular medicine (Cambridge, Mass.) · 2021Article
- Zinc is an important inter-kingdom signal between the host and microbe.Veterinary research · 2021Review
- Zinc and respiratory tract infections: Perspectives for COVID‑19 (Review).International journal of molecular medicine · 2020Review
- Genetic biosensors for imaging nitric oxide in single cells.Free radical biology & medicine · 2018Review
- Zinc deficiency primes the lung for ventilator-induced injury.JCI insight · 2017Article
- Probing the structural basis of Zn2+ regulation of the epithelial Na+ channel.The Journal of biological chemistry · 2012Article
- Functional role of intracellular labile zinc in pulmonary endothelium.Pulmonary circulation · 2012Article
- A critical role for increased labile zinc in reducing sensitivity of cultured sheep pulmonary artery endothelial cells to LPS-induced apoptosis.American journal of physiology. Lung cellular and molecular physiology · 2012Article
- Central role of manganese in regulation of stress responses, physiology, and metabolism in Streptococcus pneumoniae.Journal of bacteriology · 2010Article
- Nickel mobilizes intracellular zinc to induce metallothionein in human airway epithelial cells.American journal of respiratory cell and molecular biology · 2009Article
- Cellular zinc and redox buffering capacity of metallothionein/thionein in health and disease.Molecular medicine (Cambridge, Mass.)Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Among putative small molecules that affect sensitivity to acute lung injury, zinc and nitric oxide are potentially unique by virtue of their interdependence and dual capacities to be cytoprotective or injurious. Nitric oxide and zinc appear to be linked via an intracellular signaling pathway involving S-nitrosation of metallothoinein--itself a small protein known to be an important inducible gene product that may modify lung injury. In the present article, we summarize recent efforts using genetic and fluorescence optical imaging techniques to: (1) demonstrate that S-nitrosation of metallothionein affects intracellular zinc homeostasis in intact pulmonary endothelial cells; and (2) reveal a protective role for this pathway in hyperoxic and LPS-induced injury.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.