ReviewProceedings of the American Thoracic Society2005
Genetic determinants and ethnic disparities in sepsis-associated acute lung injury.
Review in Proceedings of the American Thoracic Society, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 46 citations in OpenAlex.
- Soluble CD14, Ischemic Stroke, and Coronary Heart Disease Risk in a Prospective Study: The REGARDS Cohort.Journal of the American Heart Association · 2020Article
- Pulmonary Endothelial Mechanical Sensing and Signaling, a Story of Focal Adhesions and Integrins in Ventilator Induced Lung Injury.Frontiers in physiology · 2019Review
- Fluid Management in Acute Respiratory Distress Syndrome: Do We Have All the FACTTs to Determine the Effect of Race?Annals of the American Thoracic Society · 2017Article
- Racial Differences in Mortality from Severe Acute Respiratory Failure in the United States, 2008-2012.Annals of the American Thoracic Society · 2016Article
- Article
- Healthcare disparities in critical illness.Critical care medicine · 2013Review
- IL1RN coding variant is associated with lower risk of acute respiratory distress syndrome and increased plasma IL-1 receptor antagonist.American journal of respiratory and critical care medicine · 2013Article
- Genome wide association identifies PPFIA1 as a candidate gene for acute lung injury risk following major trauma.PloS one · 2012Article
- ANGPT2 genetic variant is associated with trauma-associated acute lung injury and altered plasma angiopoietin-2 isoform ratio.American journal of respiratory and critical care medicine · 2011Article
- Endothelial dysfunction and claudin 5 regulation during acrolein-induced lung injury.American journal of respiratory cell and molecular biology · 2011Article
- Strain differences in alveolar neutrophil infiltration and macrophage phenotypes in an acute lung inflammation model.Molecular medicine (Cambridge, Mass.) · 2011Article
- The utility of clinical predictors of acute lung injury: towards prevention and earlier recognition.Expert review of respiratory medicine · 2010Review
- The FINNALI study on acute respiratory failure: not the final cut.Intensive care medicine · 2009Article
- Recent advances in genetic predisposition to clinical acute lung injury.American journal of physiology. Lung cellular and molecular physiology · 2009Review
- Risk factors for death after sepsis in patients immunosuppressed before the onset of sepsis.Scandinavian journal of infectious diseases · 2009Article
- Acute lung injury and the coagulation pathway: Potential role of gene polymorphisms in the protein C and fibrinolytic pathways.Intensive care medicine · 2006Review
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Acute lung injury (ALI) is a common and devastating illness that occurs in the context of sepsis and other systemic inflammatory disorders. In systemic illnesses like sepsis, only a subset of patients develops ALI even when pathologic stimuli are apparently equivalent, suggesting that there are genetic features that may influence its onset. Considerable obstacles in defining the exact nature of the pathogenesis of ALI include substantial phenotypic variance, incomplete penetrance, complex gene-environment interactions and a strong potential for locus heterogeneity. Moreover, ALI arises in a critically ill population with diverse precipitating factors and appropriate controls that best match the reference population have not been agreed upon. The sporadic nature of ALI precludes conventional approaches such as linkage mapping for the elucidation of candidate genes, but tremendous progress has been made in combining robust, genomic tools such as high-throughput, expression profiling with case-control association studies in well characterized populations. Similar to trends observed in common, complex traits such as hypertension and diabetes, some of these studies have highlighted differences in allelic variant frequencies between European American and African American ALI patients for novel genes which may explain, in part, the complex interplay between ethnicity, sepsis and the development of ALI. In trying to understand the basis for contemporary differences in allelic frequency, which may lead to differences in susceptibility, the potential role of positive selection for genetic variants in ancestral populations is considered.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.