ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2005
Disruption and recovery of patterned retinal activity in the absence of acetylcholine.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
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Who cites it
45 citing papers in PubMed.
- Cellular and Molecular Mechanisms Regulating Retinal Synapse Development.Annual review of vision science · 2024Review
- Acetylcholine Promotes Directionally Biased Glutamatergic Retinal Waves.bioRxiv : the preprint server for biology · 2023Article
- Building a circuit through correlated spontaneous neuronal activity in the developing vertebrate and invertebrate visual systems.Genes & development · 2021Review
- Spontaneous synchronous network activity in the neonatal development of mPFC in mice.Developmental neurobiology · 2021Article
- Retinal ganglion cell interactions shape the developing mammalian visual system.Development (Cambridge, England) · 2020Review
- Homeostatic plasticity in neural development.Neural development · 2018Review
- Glutamate Activity Regulates and Dendritic Development of J-RGCs.Frontiers in cellular neuroscience · 2018Article
- Retinal changes in the Tg-SwDI mouse model of Alzheimer's disease.Neuroscience · 2017Article
- Commentary: Retinal Waves Modulate an Intraretinal Circuit of Intrinsically Photosensitive Retinal Ganglion Cells.Frontiers in neural circuits · 2017Article
- Retinal Waves Modulate an Intraretinal Circuit of Intrinsically Photosensitive Retinal Ganglion Cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Prototypic and arkypallidal neurons in the dopamine-intact external globus pallidus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- DSCAM promotes refinement in the mouse retina through cell death and restriction of exploring dendrites.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Whole-Retina Reduced Electrophysiological Activity in Mice Bearing Retina-Specific Deletion of Vesicular Acetylcholine Transporter.PloS one · 2015Article
- Visual circuit development requires patterned activity mediated by retinal acetylcholine receptors.Neuron · 2014Article
- Eye-specific retinogeniculate segregation proceeds normally following disruption of patterned spontaneous retinal activity.Neural development · 2014Article
- Functional architecture of the retina: development and disease.Progress in retinal and eye research · 2014Review
- Spontaneous Network Activity and Synaptic Development.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2014Review
- A data repository and analysis framework for spontaneous neural activity recordings in developing retina.GigaScience · 2014Article
- Alteration in cellular acetylcholine influences dauer formation in Caenorhabditis elegans.BMB reports · 2014Article
- Cardiomyocyte-secreted acetylcholine is required for maintenance of homeostasis in the heart.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2013Article
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Many developing neural circuits generate synchronized bursting activity among neighboring neurons, a pattern thought to be important for sculpting precise neural connectivity. Network output remains relatively constant as the cellular and synaptic components of these immature circuits change during development, suggesting the presence of homeostatic mechanisms. In the retina, spontaneous waves of activity are present even before chemical synapse formation, needing gap junctions to propagate. However, as synaptogenesis proceeds, retinal waves become dependent on cholinergic neurotransmission, no longer requiring gap junctions. Later still in development, waves are driven by glutamatergic rather than cholinergic synapses. Here, we asked how retinal activity evolves in the absence of cholinergic transmission by using a conditional mutant in which the gene encoding choline acetyltransferase (ChAT), the sole synthetic enzyme for acetylcholine (ACh), was deleted from large retinal regions. ChAT-negative regions lacked retinal waves for the first few days after birth, but by postnatal day 5 (P5), ACh-independent waves propagated across these regions. Pharmacological analysis of the waves in ChAT knock-out regions revealed a requirement for gap junctions but not glutamate, suggesting that patterned activity may have emerged via restoration of previous gap-junctional networks. Similarly, in P5 wild-type retinas, spontaneous activity recovered after a few hours in nicotinic receptor antagonists, often as local patches of coactive cells but not waves. The rapid recovery of rhythmic spontaneous activity in the presence of cholinergic antagonists and the eventual emergence of waves in ChAT knock-out regions suggest that homeostatic mechanisms regulate retinal output during development.
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