ArticleBMC bioinformatics2005
SPdb--a signal peptide database.
Article in BMC bioinformatics, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
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Who cites it
45 citing papers in PubMed.
- Characteristics of Corynespora cassiicola, the causal agent of tobacco Corynespora leaf spot, revealed by genomic and metabolic phenomic analysis.Scientific reports · 2024Article
- Increasing the Efficiency of the Accumulation of Recombinant Proteins in Plant Cells: The Role of Transport Signal Peptides.Plants (Basel, Switzerland) · 2022Review
- DGPD: a knowledge database of dense granule proteins of the Apicomplexa.Database : the journal of biological databases and curation · 2022Article
- Article
- Review
- SPSED: A Signal Peptide Secretion Efficiency Database.Frontiers in bioengineering and biotechnology · 2021Article
- The endoplasmic reticulum P5A-ATPase is a transmembrane helix dislocase.Science (New York, N.Y.) · 2020Article
- MtSSPdb: ThePlant physiology · 2020Article
- MtSSPdb: A New Database for the Small Secreted Peptide Research Community.Plant physiology · 2020Article
- Analysis of Soybean Long Non-Coding RNAs Reveals a Subset of Small Peptide-Coding Transcripts.Plant physiology · 2020Article
- Two Tachykinin-Related Peptides with Antimicrobial Activity Isolated fromMicrobiology insights · 2020Article
- Circadian control of the secretory pathway maintains collagen homeostasis.Nature cell biology · 2020Article
- Extension of the Pompe mutation database by linking disease-associated variants to clinical severity.Human mutation · 2019Article
- A comprehensive in silico characterization of bacterial signal peptides for the excretory production of3 Biotech · 2018Article
- Article
- An att site-based recombination reporter system for genome engineering and synthetic DNA assembly.BMC biotechnology · 2017Article
- Neprosin, a Selective Prolyl Endoprotease for Bottom-up Proteomics and Histone Mapping.Molecular & cellular proteomics : MCP · 2017Article
- Kingdom-Wide Analysis of Fungal Small Secreted Proteins (SSPs) Reveals their Potential Role in Host Association.Frontiers in plant science · 2016Article
- LocSigDB: a database of protein localization signals.Database : the journal of biological databases and curation · 2015Article
- Secretome analysis reveals effector candidates associated with broad host range necrotrophy in the fungal plant pathogen Sclerotinia sclerotiorum.BMC genomics · 2014Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe signal peptide plays an important role in protein targeting and protein translocation in both prokaryotic and eukaryotic cells. This transient, short peptide sequence functions like a postal address on an envelope by targeting proteins for secretion or for transfer to specific organelles for further processing. Understanding how signal peptides function is crucial in predicting where proteins are translocated. To support this understanding, we present SPdb signal peptide database http://proline.bic.nus.edu.sg/spdb, a repository of experimentally determined and computationally predicted signal peptides.
resultsSPdb integrates information from two sources (a) Swiss-Prot protein sequence database which is now part of UniProt and (b) EMBL nucleotide sequence database. The database update is semi-automated with human checking and verification of the data to ensure the correctness of the data stored. The latest release SPdb release 3.2 contains 18,146 entries of which 2,584 entries are experimentally verified signal sequences; the remaining 15,562 entries are either signal sequences that fail to meet our filtering criteria or entries that contain unverified signal sequences.
conclusionSPdb is a manually curated database constructed to support the understanding and analysis of signal peptides. SPdb tracks the major updates of the two underlying primary databases thereby ensuring that its information remains up-to-date.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.