ReviewDie Naturwissenschaften2005
Molecular mechanisms of optic axon guidance.
Review in Die Naturwissenschaften, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 29 citations in OpenAlex.
- Impact of inflammation on developing respiratory control networks: rhythm generation, chemoreception and plasticity.Respiratory physiology & neurobiology · 2020Review
- Exome sequencing identifies a novel UNC5D mutation in a severe myopic anisometropia family: A case report.Medicine · 2017Article
- Highly effective photonic cue for repulsive axonal guidance.PloS one · 2014Article
- Renin-angiotensin system involvement in the oxidative stress-induced neurodegeneration of cultured retinal ganglion cells.Japanese journal of ophthalmology · 2013Article
- Analysis of axon guidance defects at the optic chiasm in heparan sulphate sulphotransferase compound mutant mice.Journal of anatomy · 2011Article
- Heparan sulfate regulates intraretinal axon pathfinding by retinal ganglion cells.Investigative ophthalmology & visual science · 2011Article
- Development of the retina and optic pathway.Vision research · 2011Review
- Concerted action of CB1 cannabinoid receptor and deleted in colorectal cancer in axon guidance.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- Pontine tegmental cap dysplasia: MR imaging and diffusion tensor imaging features of impaired axonal navigation.AJNR. American journal of neuroradiology · 2009Article
- Regenerating the central nervous system: how easy for planarians!Development genes and evolution · 2007Review
- [Morphology of the optic chiasm in albinism].Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft · 2007Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Axon guidance is one of the critical processes during vertebrate central nervous system (CNS) development. The optic nerve, which contains the axons of retinal ganglion cells, has been used as a powerful model to elucidate some of the mechanisms underlying axon guidance because it is easily manipulated experimentally, and its function is well understood. Recent molecular biology studies have revealed that numerous guidance molecules control the development of the visual pathway. This review introduces the molecular mechanisms involved in each critical step during optic axon guidance. Axonal projections to the optic disc are thought to depend on adhesion molecules and inhibitory extracellular matrices such as chondroitin sulfate. The formation of the head of the optic nerve and the optic chiasm require ligand-receptor interactions between netrin-1 and the deleted in colorectal cancer receptor, and Slit proteins and Robo receptors, respectively. The gradient distributions of ephrin ligands and Eph receptors are essential for correct ipsilateral projections at the optic chiasm and the topographic mapping of axons in the superior colliculus/optic tectum. The precise gradient is regulated by transcription factors determining the retinal dorso-ventral and nasal-temporal polarities. Moreover, the axon guidance activities by Slit and semaphorin 5A require the existence of heparan sulfate, which binds to numerous guidance molecules. Recent discoveries about the molecular mechanisms underlying optic nerve guidance will facilitate progress in CNS developmental biology and axon-regeneration therapy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.