ArticleDevelopment genes and evolution2006
Miple1 and miple2 encode a family of MK/PTN homologues in Drosophila melanogaster.
Article in Development genes and evolution, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed, 41 citations in OpenAlex.
- Midkine: A Cancer Biomarker Candidate and Innovative Therapeutic Approaches.European journal of breast health · 2024Article
- Midkine-A novel player in cardiovascular diseases.Frontiers in cardiovascular medicine · 2022Review
- The Role of Midkine in Arteriogenesis, Involving Mechanosensing, Endothelial Cell Proliferation, and Vasodilation.International journal of molecular sciences · 2018Review
- Midkine: A Novel Biomarker to Predict Malignancy in Patients with Nodular Thyroid Disease.International journal of endocrinology · 2016Article
- Structure and function of midkine as the basis of its pharmacological effects.British journal of pharmacology · 2014Review
- Midkine in host defence.British journal of pharmacology · 2014Review
- Involvement of midkine in neuroblastoma tumourigenesis.British journal of pharmacology · 2014Review
- Article
- Pleiotrophin as a central nervous system neuromodulator, evidences from the hippocampus.Frontiers in cellular neuroscience · 2014Review
- Nemo regulates cell dynamics and represses the expression of miple, a midkine/pleiotrophin cytokine, during ommatidial rotation.Developmental biology · 2013Article
- Midkine in inflammation.TheScientificWorldJournal · 2011Review
- Midkine: a promising molecule for drug development to treat diseases of the central nervous system.Current pharmaceutical design · 2011Review
- Midkine and pleiotrophin have bactericidal properties: preserved antibacterial activity in a family of heparin-binding growth factors during evolution.The Journal of biological chemistry · 2010Article
- Midkine, a heparin-binding cytokine with multiple roles in development, repair and diseases.Proceedings of the Japan Academy. Series B, Physical and biological sciences · 2010Review
- Pleiotrophin is expressed in avian somites and tendon anlagen.Histochemistry and cell biology · 2009Article
- Anaplastic lymphoma kinase: signalling in development and disease.The Biochemical journal · 2009Review
- Anaplastic lymphoma kinase: role in cancer pathogenesis and small-molecule inhibitor development for therapy.Expert review of anticancer therapy · 2009Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Midkine (MK) and Pleiotrophin (PTN) are small heparin-binding cytokines with closely related structures. To date, this family of proteins has been implicated in multiple processes, such as growth, survival, and migration of various cells, and has roles in neurogenesis and epithelial-mesenchymal interaction during organogenesis. In this report, we have characterized two members of the MK/PTN family of proteins in Drosophila, named Miple1 and Miple2, from Midkine and Pleiotrophin. Drosophila miple1 and miple2 encode secreted proteins which are expressed in spatially restricted, nonoverlapping patterns during embryogenesis. Expression of miple1 can be found at high levels in the central nervous system, while miple2 is strongly expressed in the developing midgut endoderm. The identification of homologues of the MK/PTN family in this genetically tractable model organism should allow an analysis of their function during complex developmental processes.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.