ArticleCell biology education2005
An inquiry into protein structure and genetic disease: introducing undergraduates to bioinformatics in a large introductory course.
Article in Cell biology education, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed.
- Quantitative Analysis of the Trends Exhibited by the Three Interdisciplinary Biological Sciences: Biophysics, Bioinformatics, and Systems Biology.Journal of microbiology & biology education · 2015Article
- A comprehensive faculty, staff, and student training program enhances student perceptions of a course-based research experience at a two-year institution.CBE life sciences education · 2014Article
- A survey of scholarly literature describing the field of bioinformatics education and bioinformatics educational research.CBE life sciences education · 2014Review
- Building the next generation of quantitative biologists.Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing · 2014Article
- A critical analysis of assessment quality in genomics and bioinformatics education research.CBE life sciences education · 2013Article
- Graduate education. Interdisciplinary graduate training in teaching labs.Science (New York, N.Y.) · 2012Article
- Is non-union of tibial shaft fractures due to nonculturable bacterial pathogens? A clinical investigation using PCR and culture techniques.Journal of orthopaedic surgery and research · 2012Article
- A Bioinformatics Module for Use in an Introductory Biology Laboratory.The American biology teacher · 2012Article
- Article
- Teaching synthetic biology, bioinformatics and engineering to undergraduates: the interdisciplinary Build-a-Genome course.Genetics · 2009Article
- Tonal interface to MacroMolecules (TIMMol): A textual and tonal tool for molecular visualization.Biochemistry and molecular biology education : a bimonthly publication of the International Union of Biochemistry and Molecular Biology · 2008Article
- Article
- Exploring DNA structure with Cn3D.CBE life sciences education · 2007Article
- Genome science: a video tour of the Washington University Genome Sequencing Center for high school and undergraduate students.Cell biology education · 2005Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This inquiry-based lab is designed around genetic diseases with a focus on protein structure and function. To allow students to work on their own investigatory projects, 10 projects on 10 different proteins were developed. Students are grouped in sections of 20 and work in pairs on each of the projects. To begin their investigation, students are given a cDNA sequence that translates into a human protein with a single mutation. Each case results in a genetic disease that has been studied and recorded in the Online Mendelian Inheritance in Man (OMIM) database. Students use bioinformatics tools to investigate their proteins and form a hypothesis for the effect of the mutation on protein function. They are also asked to predict the impact of the mutation on human physiology and present their findings in the form of an oral report. Over five laboratory sessions, students use tools on the National Center for Biotechnology Information (NCBI) Web site (BLAST, LocusLink, OMIM, GenBank, and PubMed) as well as ExPasy, Protein Data Bank, ClustalW, the Kyoto Encyclopedia of Genes and Genomes (KEGG) database, and the structure-viewing program DeepView. Assessment results showed that students gained an understanding of the Web-based databases and tools and enjoyed the investigatory nature of the lab.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.