ArticleAJNR. American journal of neuroradiology2005
Diffusion-tensor MR imaging of the brain in human immunodeficiency virus-positive patients.
Article in AJNR. American journal of neuroradiology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers, 1 of them a synthesis that pooled it.
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Who cites it
52 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Reliability of White Matter Microstructural Changes in HIV Infection: Meta-Analysis and Confirmation.AJNR. American journal of neuroradiology · 2017Pooled it
- Relationship of prospective memory to neuropsychological function and antiretroviral adherence.Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists · 2009Trial
- Multishell diffusion MRI reveals whole-brain white matter changes in HIV.Human brain mapping · 2023Article
- Longitudinal white matter alterations in SIVmac239-infected rhesus monkeys with and without regular cART treatment.Frontiers in immunology · 2022Article
- Diffusion tensor magnetic resonance imaging of white matter integrity in patients with HIV-associated neurocognitive disorders.Annals of translational medicine · 2020Article
- White matter microstructure among perinatally HIV-infected youth: a diffusion tensor imaging study.Journal of neurovirology · 2019Article
- Article
- Risk Factors and Pathogenesis of HIV-Associated Neurocognitive Disorder: The Role of Host Genetics.International journal of molecular sciences · 2018Review
- Magnetic Resonance Imaging Evidence for Human Immunodeficiency Virus Effects on Central Auditory Processing: A Review.Journal of AIDS & clinical research · 2017Article
- Cocaine dependence does not contribute substantially to white matter abnormalities in HIV infection.Journal of neurovirology · 2017Article
- Topological Organization of Whole-Brain White Matter in HIV Infection.Brain connectivity · 2017Article
- Short-Term Internet-Search Training Is Associated with Increased Fractional Anisotropy in the Superior Longitudinal Fasciculus in the Parietal Lobe.Frontiers in neuroscience · 2017Article
- Early Antiretroviral Therapy in HIV-Infected Children Is Associated with Diffuse White Matter Structural Abnormality and Corpus Callosum Sparing.AJNR. American journal of neuroradiology · 2016Article
- The impact of human immune deficiency virus and hepatitis C coinfection on white matter microstructural integrity.Journal of neurovirology · 2016Article
- Age exacerbates HIV-associated white matter abnormalities.Journal of neurovirology · 2016Article
- Human immunodeficiency virus has similar effects on brain volumetrics and cognition in males and females.Journal of neurovirology · 2016Article
- White matter deficits assessed by diffusion tensor imaging and cognitive dysfunction in psychostimulant users with comorbid human immunodeficiency virus infection.BMC research notes · 2015Article
- White matter microstructure among youth with perinatally acquired HIV is associated with disease severity.AIDS (London, England) · 2015Article
- Diffusion tensor MR imaging of white matter integrity in HIV-positive patients with planning deficit.Neuroradiology · 2015Article
- Cerebral white matter integrity during primary HIV infection.AIDS (London, England) · 2015Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background and purposeThere is early evidence that diffusion-tensor imaging (DTI) is useful in demonstrating subtle white matter alterations in different diseases of brain. We hypothesize that DTI in several brain regions in human immunodeficiency virus-positive (HIV+) patients is useful in the early detection of HIV-related brain injury.
methodsMR imaging and DTI were performed in 60 HIV+ patients and in 30 controls. Fractional anisotropy (FA) and apparent diffusion coefficient (ADC; mm/s(2)) maps were generated and coregistered on T2-weighted images. Regions of interest were placed in the splenium and genu of the callosum, the frontal white matter, and the hippocampus. HIV+ patients were divided into those whose CD4 count were <250 cells/mm(3) or >250 cells/mm(3). According to plasma viral loads, patients were divided into those whose viral loads were <50 copies/mL, 50-100,000 copies/mL, or >100,000 copies/mL.
resultsStatistically significant decrease of FA was found in the genu of the corpus callosum in HIV+ patients compared with controls. FA was reduced in the frontal white matter and hippocampi in HIV+ patients compared with controls. Differences, however, were not statistically significant. No statistically significant differences were found between the HIV+ groups for FA of the splenium or between these groups and the controls. ADC values were significantly increased in the genu of HIV+ patients when compared with controls and were also increased in other locations, but without statistical significance.
conclusionAs used in this study, DTI was not helpful in identifying patients with early HIV infection.
Indexed as
Identifiers
16219833PMC7976135What OpenQuestion holds
Registered trials
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