ArticleAJNR. American journal of neuroradiology2005
Evaluation of treatment-induced cerebral white matter injury by using diffusion-tensor MR imaging: initial experience.
Article in AJNR. American journal of neuroradiology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Diagnostic Value of Magnetic Resonance Spectroscopy in Radiation Encephalopathy Induced by Radiotherapy for Patients with Nasopharyngeal Carcinoma: A Meta-Analysis.BioMed research international · 2016Pooled it
- Effect of the Maximum Dose on White Matter Fiber Bundles Using Longitudinal Diffusion Tensor Imaging.International journal of radiation oncology, biology, physics · 2016Trial
- Diffusion tensor imaging screening of radiation-induced changes in the white matter after prophylactic cranial irradiation of patients with small cell lung cancer: first results of a prospective study.AJNR. American journal of neuroradiology · 2008Trial
- Radiation Effects on Normal Brain in Subjects With Recurrent Glioblastoma by Spectroscopic MRI.NMR in biomedicine · 2026Article
- Early region-specific impact of adjuvant radiation therapy on cognition and quality of life in adult patients with primary brain tumors.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2025Article
- Voxel based morphometry-detected white matter volume loss after multi-modality treatment in high grade glioma patients.PloS one · 2023Article
- Review
- Application of a machine learning method to whole brain white matter injury after radiotherapy for nasopharyngeal carcinoma.Cancer imaging : the official publication of the International Cancer Imaging Society · 2019Article
- Structural MRI research in patients with nasopharyngeal carcinoma following radiotherapy: A DTI and VBM study.Oncology letters · 2017Article
- Neuroimaging of Peptide-based Vaccine Therapy in Pediatric Brain Tumors: Initial Experience.Neuroimaging clinics of North America · 2017Review
- Whole-brain changes in white matter microstructure after radiotherapy for nasopharyngeal carcinoma: a diffusion tensor imaging study.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2016Article
- Assessment of early response to tumor-treating fields in newly diagnosed glioblastoma using physiologic and metabolic MRI: initial experience.CNS oncology · 2016Article
- Modern brain tumor imaging.Brain tumor research and treatment · 2015Review
- Differentiating tumor recurrence from treatment necrosis: a review of neuro-oncologic imaging strategies.Neuro-oncology · 2013Review
- Distinction between postoperative recurrent glioma and radiation injury using MR diffusion tensor imaging.Neuroradiology · 2010Article
- Neuroimaging and neuropsychological follow-up study in a pediatric brain tumor patient treated with surgery and radiation.Neurocase · 2010Article
- Maintenance of white matter integrity in a rat model of radiation-induced cognitive impairment.Journal of the neurological sciences · 2009Article
- MR spectroscopy in radiation injury.AJNR. American journal of neuroradiology · 2009Review
- Serial diffusion tensor imaging to characterize radiation-induced changes in normal-appearing white matter following radiotherapy in patients with adult low-grade gliomas.Radiation medicine · 2008Article
- Diffusion-weighted imaging of the brain in infants and children.Pediatric radiology · 2007Review
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background and purposeTreatment with chemotherapy and radiation therapy for brain tumors can cause white matter (WM) injury. Conventional MR imaging, however, cannot always depict treatment-induced transient WM abnormalities. We investigated the ability of diffusion-tensor (DT) MR imaging and proton MR spectroscopy to detect the treatment-induced transient changes within normal-appearing WM.
methodsDT MR imaging and proton MR spectroscopy were performed in 8 patients treated with a combination of surgery, chemotherapy, and radiation therapy for brain tumors (17 examinations) and 11 age-matched controls. Apparent diffusion coefficient (ADC) value, fractional anisotropy (FA) value, and N-acetylaspartate (NAA)/creatine (Cr) ratio were obtained from 27 hemispheres with normal-appearing WM in the patients. We divided the datasets of isotropic ADC, FA, and NAA/Cr, on the basis of the time period after completion of radiation therapy, into 4 groups: group 1 (0-2 months; n = 10), group 2 (3-5 months; n = 5), group 3 (6-9 months; n = 7), and group 4 (10-12 months; n = 5). We compared averages of mean isotropic ADC, mean FA, and NAA/Cr of each patient group with those of the control group by using a t test.
resultsIn the group 2, averages of mean FA and NAA/Cr decreased and average of mean isotopic ADC increased in comparison with those of the control group (P = .004, .04, and .0085, respectively). There were no significant differences in the averages between the control group and patient groups 1, 3, and 4.
conclusionDT MR imaging and proton MR spectroscopy can provide quantitative indices that may reflect treatment-induced transient derangement of normal-appearing WM.
Indexed as
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16219822PMC7976122What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.