ArticleGenetics2006
The mop1 (mediator of paramutation1) mutant progressively reactivates one of the two genes encoded by the MuDR transposon in maize.
Article in Genetics, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed.
- RNA-directed DNA methylation mutants reduce histone methylation at the paramutated maize booster1 enhancer.Plant physiology · 2024Article
- Heritable changes of epialleles near genes in maize can be triggered in the absence of CHH methylation.Plant physiology · 2024Article
- From parasites to partners: exploring the intricacies of host-transposon dynamics and coevolution.Functional & integrative genomics · 2023Review
- Epigenetic Regulation During Plant Development and the Capacity for Epigenetic Memory.Annual review of plant biology · 2023Review
- A Molecular Cloning and Sanger Sequencing-based Protocol for Detecting Site-specific DNA Methylation.Bio-protocol · 2022Article
- RNA-directed DNA methylation prevents rapid and heritable reversal of transposon silencing under heat stress in Zea mays.PLoS genetics · 2021Article
- Silencing ofGenetics · 2020Article
- Dynamic Patterns of Transcript Abundance of Transposable Element Families in Maize.G3 (Bethesda, Md.) · 2019Article
- Loss of RNA-Directed DNA Methylation in Maize Chromomethylase and DDM1-Type Nucleosome Remodeler Mutants.The Plant cell · 2018Article
- Subtle Perturbations of the Maize Methylome Reveal Genes and Transposons Silenced by Chromomethylase or RNA-Directed DNA Methylation Pathways.G3 (Bethesda, Md.) · 2018Article
- Article
- Genome-Wide Characterization of Maize Small RNA Loci and Their Regulation in the required to maintain repression6-1 (rmr6-1) Mutant and Long-Term Abiotic Stresses.Plant physiology · 2016Article
- RNA-directed DNA methylation enforces boundaries between heterochromatin and euchromatin in the maize genome.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Transposition of a rice Mutator-like element in the yeast Saccharomyces cerevisiae.The Plant cell · 2015Article
- Chromatin structure and gene expression changes associated with loss of MOP1 activity in Zea mays.Epigenetics · 2014Article
- A MITE transposon insertion is associated with differential methylation at the maize flowering time QTL Vgt1.G3 (Bethesda, Md.) · 2014Article
- Reactivation of a silenced minimal Mutator transposable element system following low-energy nitrogen ion implantation in maize.Plant cell reports · 2010Article
- RNA-mediated trans-communication can establish paramutation at the b1 locus in maize.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- Mutator transposon activation after UV-B involves chromatin remodeling.Epigenetics · 2010Article
- A comparative approach to the principal mechanisms of different memory systems.Die Naturwissenschaften · 2009Review
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3 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Transposons make up a sizable portion of most genomes, and most organisms have evolved mechanisms to silence them. In maize, silencing of the Mutator family of transposons is associated with methylation of the terminal inverted repeats (TIRs) surrounding the autonomous element and loss of mudrA expression (the transposase) as well as mudrB (a gene involved in insertional activity). We have previously reported that a mutation that suppresses paramutation in maize, mop1, also hypomethylates Mu1 elements and restores somatic activity to silenced MuDR elements. Here, we describe the progressive reactivation of silenced mudrA after several generations in a mop1 background. In mop1 mutants, the TIRA becomes hypomethylated immediately, but mudrA expression and significant somatic reactivation is not observed until silenced MuDR has been exposed to mop1 for several generations. In subsequent generations, individuals that are heterozygous or wild type for the Mop1 allele continue to exhibit hypomethylation at Mu1 and mudrA TIRs as well as somatic activity and high levels of mudrA expression. Thus, mudrA silencing can be progressively and heritably reversed. Conversely, mudrB expression is never restored, its TIR remains methylated, and new insertions of Mu elements are not observed. These data suggest that mudrA and mudrB silencing may be maintained via distinct mechanisms.
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