ArticleGenetics2006
Genetic analysis of Saccharomyces cerevisiae H2A serine 129 mutant suggests a functional relationship between H2A and the sister-chromatid cohesion partners Csm3-Tof1 for the repair of topoisomerase I-induced DNA damage.
Article in Genetics, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 43 citations in OpenAlex.
- Mechanisms controlling replication fork stalling and collapse at topoisomerase 1 cleavage complexes.Molecular cell · 2024Article
- Screening for cold tolerance genes in C. elegans, whose expressions are affected by anticancer drugs camptothecin and leptomycin B.Scientific reports · 2024Article
- Post-transcriptional regulation ofAutophagy · 2022Article
- Approaching Protein Barriers: Emerging Mechanisms of Replication Pausing in Eukaryotes.Frontiers in cell and developmental biology · 2021Review
- Separable functions of Tof1/Timeless in intra-S-checkpoint signalling, replisome stability and DNA topological stress.Nucleic acids research · 2020Article
- Cryo-EM Structure of the Fork Protection Complex Bound to CMG at a Replication Fork.Molecular cell · 2020Article
- Fork pausing complex engages topoisomerases at the replisome.Genes & development · 2020Article
- Chromatin determinants impart camptothecin sensitivity.EMBO reports · 2017Article
- The Role of DNA Mismatch Repair and Recombination in the Processing of DNA Alkylating Damage in Living Yeast Cells.Advances in bioscience and biotechnology (Print) · 2015Article
- Tipin functions in the protection against topoisomerase I inhibitor.The Journal of biological chemistry · 2014Article
- Overexpression of cohesion establishment factor DSCC1 through E2F in colorectal cancer.PloS one · 2014Article
- Dissection of DNA damage responses using multiconditional genetic interaction maps.Molecular cell · 2013Article
- Selective ploidy ablation, a high-throughput plasmid transfer protocol, identifies new genes affecting topoisomerase I-induced DNA damage.Genome research · 2011Article
- Roles for Gcn5 in promoting nucleosome assembly and maintaining genome integrity.Cell cycle (Georgetown, Tex.) · 2010Article
- Article
- The jmjN and jmjC domains of the yeast zinc finger protein Gis1 interact with 19 proteins involved in transcription, sumoylation and DNA repair.Molecular genetics and genomics : MGG · 2007Article
- Repair of topoisomerase I-mediated DNA damage.Progress in nucleic acid research and molecular biology · 2006Review
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Collision between a topoisomerase I-DNA intermediate and an advancing replication fork represents a unique form of replicative damage. We have shown previously that yeast H2A serine 129 is involved in the recovery from this type of damage. We now report that efficient repair also requires proteins involved in chromatid cohesion: Csm3; Tof1; Mrc1, and Dcc1. Epistasis analysis defined several pathways involving these proteins. Csm3 and Tof1 function in a same pathway and downstream of H2A. In addition, the pathway involving H2A/Csm3/Tof1 is distinct from the pathways involving the Ctf8/Ctf18/Dcc1 complex, the Rad9 pathway, and another involving Mrc1. Our genetic studies suggest a role for H2A serine 129 in the establishment of specialized cohesion structure necessary for the normal repair of topoisomerase I-induced DNA damage.
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