ArticleGenetics2006
Detection of genes for ordinal traits in nuclear families and a unified approach for association studies.
Article in Genetics, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 22 citations in OpenAlex.
- Genetic association tests in family samples for multi-category phenotypes.BMC genomics · 2021Article
- Generalized multifactor dimensionality reduction approaches to identification of genetic interactions underlying ordinal traits.Genetic epidemiology · 2019Article
- Residuals and Diagnostics for Ordinal Regression Models: A Surrogate Approach.Journal of the American Statistical Association · 2018Article
- Association detection between ordinal trait and rare variants based on adaptive combination of P values.Journal of human genetics · 2018Article
- Probability-scale residuals for continuous, discrete, and censored data.The Canadian journal of statistics = Revue canadienne de statistique · 2016Article
- Association Tests of Multiple Phenotypes: ATeMP.PloS one · 2015Article
- Identifying Genetic Variants for Addiction via Propensity Score Adjusted Generalized Kendall's Tau.Journal of the American Statistical Association · 2014Article
- Genetic association test for multiple traits at gene level.Genetic epidemiology · 2013Article
- Nonparametric Covariate-Adjusted Association Tests Based on the Generalized Kendall's Tau().Journal of the American Statistical Association · 2012Article
- Propensity score-based nonparametric test revealing genetic variants underlying bipolar disorder.Genetic epidemiology · 2011Article
- Statistical Analysis in Genetic Studies of Mental Illnesses.Statistical science : a review journal of the Institute of Mathematical Statistics · 2011Article
- Article
- An Association Test for Multiple Traits Based on the Generalized Kendall's Tau.Journal of the American Statistical Association · 2010Article
- Variance-components methods for linkage and association analysis of ordinal traits in general pedigrees.Genetic epidemiology · 2010Article
- Why Do We Test Multiple Traits in Genetic Association Studies?Journal of the Korean Statistical Society · 2009Article
- A tree-based method for modeling a multivariate ordinal response.Statistics and its interface · 2008Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
There is growing interest in genomewide association analysis using single-nucleotide polymorphisms (SNPs), because traditional linkage studies are not as powerful in identifying genes for common, complex diseases. Tests for linkage disequilibrium have been developed for binary and quantitative traits. However, since many human conditions and diseases are measured in an ordinal scale, methods need to be developed to investigate the association of genes and ordinal traits. Thus, in the current report we propose and derive a score test statistic that identifies genes that are associated with ordinal traits when gametic disequilibrium between a marker and trait loci exists. Through simulation, the performance of this new test is examined for both ordinal traits and quantitative traits. The proposed statistic not only accommodates and is more powerful for ordinal traits, but also has similar power to that of existing tests when the trait is quantitative. Therefore, our proposed statistic has the potential to serve as a unified approach to identifying genes that are associated with any trait, regardless of how the trait is measured. We further demonstrated the advantage of our test by revealing a significant association (P = 0.00067) between alcohol dependence and a SNP in the growth-associated protein 43.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.