ArticleDevelopmental dynamics : an official publication of the American Association of Anatomists2005
Inner ear formation during the early larval development of Xenopus laevis.
Article in Developmental dynamics : an official publication of the American Association of Anatomists, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 41 citations in OpenAlex.
- Transcriptomic Analysis Identifies Candidate Genes for Differential Expression duringbioRxiv : the preprint server for biology · 2024Article
- Article
- Locomotion-induced ocular motor behavior in larval Xenopus is developmentally tuned by visuo-vestibular reflexes.Nature communications · 2022Article
- The early development and physiology ofJournal of neurophysiology · 2021Article
- Exploring the ontogenetic development of the inner ear in Aardvarks.Journal of anatomy · 2021Article
- Otic Neurogenesis inFrontiers in neuroanatomy · 2021Article
- Six1 proteins with human branchio-oto-renal mutations differentially affect cranial gene expression and otic development.Disease models & mechanisms · 2020Article
- Tadpole bioacoustics: Sound processing across metamorphosis.Behavioral neuroscience · 2019Review
- Topologically correct central projections of tetrapod inner ear afferents require Fzd3.Scientific reports · 2019Article
- Pa2G4 is a novel Six1 co-factor that is required for neural crest and otic development.Developmental biology · 2017Article
- Ontogenetic Development of Vestibulo-Ocular Reflexes in Amphibians.Frontiers in neural circuits · 2016Review
- Molecular asymmetry in the 8-cell stage Xenopus tropicalis embryo described by single blastomere transcript sequencing.Developmental biology · 2015Article
- RNA-Seq and microarray analysis of the Xenopus inner ear transcriptome discloses orthologous OMIM(®) genes for hereditary disorders of hearing and balance.BMC research notes · 2015Article
- Sp8 regulates inner ear development.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Vestibular lesion-induced developmental plasticity in spinal locomotor networks during Xenopus laevis metamorphosis.PloS one · 2013Article
- Probing the Xenopus laevis inner ear transcriptome for biological function.BMC genomics · 2012Article
- Long-term consequences of Sox9 depletion on inner ear development.Developmental dynamics : an official publication of the American Association of Anatomists · 2010Article
- EYA1 mutations associated with the branchio-oto-renal syndrome result in defective otic development in Xenopus laevis.Biology of the cell · 2010Article
- Development of multisensory convergence in the Xenopus optic tectum.Journal of neurophysiology · 2009Article
- Localization of Kv2.2 protein in Xenopus laevis embryos and tadpoles.The Journal of comparative neurology · 2008Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The formation of the eight independent endorgan compartments (sacculus, utricle, horizontal canal, anterior canal, posterior canal, lagena, amphibian papilla, and basilar papilla) of the Xenopus laevis inner ear is illustrated as the otic vesicle develops into a complex labyrinthine structure. The morphology of transverse sections and whole-mounts of the inner ear was assessed in seven developmental stages (28, 31, 37, 42, 45, 47, 50) using brightfield and laser scanning confocal microscopy. The presence of mechanosensory hair cells in the sensory epithelia was determined by identification of stereociliary bundles in cryosectioned tissue and whole-mounts of the inner ear labeled with the fluorescent F-actin probe Alexa-488 phalloidin. Between stages 28 and 45, the otic vesicle grows in size, stereociliary bundles appear and increase in number, and the pars inferior and pars superior become visible. The initial formation of vestibular compartments with their nascent stereociliary bundles is seen by larval stage 47, and all eight vestibular and auditory compartments with their characteristic sensory fields are present by larval stage 50. Thus, in Xenopus, inner ear compartments are established between stages 45 and 50, a 2-week period during which the ear quadruples in length in the anteroposterior dimension. The anatomical images presented here demonstrate the morphological changes that occur as the otic vesicle forms the auditory and vestibular endorgans of the inner ear. These images provide a resource for investigations of gene expression patterns in Xenopus during inner ear compartmentalization and morphogenesis.
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