ArticlePflugers Archiv : European journal of physiology2006
Ischemia-induced increase of stiffness of alphaB-crystallin/HSPB2-deficient myocardium.
Article in Pflugers Archiv : European journal of physiology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
26 citing papers in PubMed, 46 citations in OpenAlex.
- Effects of geranylgeranylacetone on diastolic and microvascular function in patients with heart failure with a preserved ejection fraction: A phase 2, randomized, placebo-controlled, crossover trial.European journal of heart failure · 2025Trial
- Oxidative stress and inflammation distinctly drive molecular mechanisms of diastolic dysfunction and remodeling in female and male heart failure with preserved ejection fraction rats.Frontiers in cardiovascular medicine · 2023Article
- Insights on Human Small Heat Shock Proteins and Their Alterations in Diseases.Frontiers in molecular biosciences · 2022Review
- Neuromuscular Diseases Due to Chaperone Mutations: A Review and Some New Results.International journal of molecular sciences · 2020Review
- Modulation of Titin-Based Stiffness in Hypertrophic Cardiomyopathy via Protein Kinase D.Frontiers in physiology · 2020Article
- Review
- Cardiac contractility modulation: mechanisms of action in heart failure with reduced ejection fraction and beyond.European journal of heart failure · 2019Review
- Subchronic nandrolone administration reduces cardiac oxidative markers during restraint stress by modulating protein expression patterns.Molecular and cellular biochemistry · 2017Article
- Upregulation and phosphorylation of HspB1/Hsp25 and HspB5/αB-crystallin after transient middle cerebral artery occlusion in rats.Cell stress & chaperones · 2017Article
- The protective role of small heat shock proteins in cardiac diseases: key role in atrial fibrillation.Cell stress & chaperones · 2017Review
- AFM study shows prominent physical changes in elasticity and pericellular layer in human acute leukemic cells due to inadequate cell-cell communication.Nanotechnology · 2016Article
- Biophysical differences between chronic myelogenous leukemic quiescent and proliferating stem/progenitor cells.Nanomedicine : nanotechnology, biology, and medicine · 2016Article
- HspB5/αB-crystallin increases dendritic complexity and protects the dendritic arbor during heat shock in cultured rat hippocampal neurons.Cellular and molecular life sciences : CMLS · 2016Article
- Induction and phosphorylation of the small heat shock proteins HspB1/Hsp25 and HspB5/αB-crystallin in the rat retina upon optic nerve injury.Cell stress & chaperones · 2016Article
- Article
- Human myocytes are protected from titin aggregation-induced stiffening by small heat shock proteins.The Journal of cell biology · 2014Article
- Quantitative study of the elastic modulus of loosely attached cells in AFM indentation experiments.Biophysical journal · 2013Article
- Reductive stress linked to small HSPs, G6PD, and Nrf2 pathways in heart disease.Antioxidants & redox signaling · 2013Review
- Small heat shock proteins in redox metabolism: implications for cardiovascular diseases.The international journal of biochemistry & cell biology · 2012Review
- Phosphorylation-dependent subcellular localization of the small heat shock proteins HspB1/Hsp25 and HspB5/αB-crystallin in cultured hippocampal neurons.Histochemistry and cell biology · 2012Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
The two small heat shock proteins (sHSPs), alphaB-crystallin and HSPB2, have been shown to translocate within a few minutes of cardiac ischemia from the cytosol to myofibrils; and it has been suggested that their chaperone-like properties might protect myofibrillar proteins from unfolding or aggregation during stress conditions. Further evidence of an important role for HSPs in muscle function is provided by the fact that mutations of the alphaB-crystallin gene cause myopathy and cardiomyopathy. In the present study, we subjected isolated papillary muscles of alphaB-crystallin/HSPB2-deficient mice to simulated ischemia and reperfusion. During ischemia in alphaB-crystallin/HSPB2-deficient muscles, the development of contracture started earlier and reached a higher value compared to the wildtype mice. The recovery of contracture of alphaB-crystallin/HSPB2-deficient muscles was also attenuated during the simulated reperfusion period. However, twitch force was not significantly altered at any time of the experiment. This suggests that during ischemic insults, alphaB-crystallin/HSPB2 may not be important for the contraction process itself, but rather serve to maintain muscular elasticity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.