ArticleProceedings of the National Academy of Sciences of the United States of America2005
The evolutionary origin of a complex scrambled gene.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- OrthoVenn3: an integrated platform for exploring and visualizing orthologous data across genomes.Nucleic acids research · 2023Article
- Comparative genomics reveals insight into the evolutionary origin of massively scrambled genomes.eLife · 2022Article
- Programmed genome rearrangements in ciliates.Cellular and molecular life sciences : CMLS · 2020Review
- SIGAR: Inferring Features of Genome Architecture and DNA Rearrangements by Split-Read Mapping.Genome biology and evolution · 2020Article
- Programmed genome rearrangements in Oxytricha produce transcriptionally active extrachromosomal circular DNA.Nucleic acids research · 2019Article
- Russian Doll Genes and Complex Chromosome Rearrangements inG3 (Bethesda, Md.) · 2018Article
- Recurring patterns among scrambled genes in the encrypted genome of the ciliate Oxytricha trifallax.Journal of theoretical biology · 2016Article
- Nuclear Noncoding RNAs and Genome Stability.Molecular cell · 2016Review
- Evolution of the Exon-Intron Structure in Ciliate Genomes.PloS one · 2016Article
- Combinatorial DNA Rearrangement Facilitates the Origin of New Genes in Ciliates.Genome biology and evolution · 2015Article
- Programmed Genome Rearrangements in the Ciliate Oxytricha.Microbiology spectrum · 2014Review
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- RNA-Mediated Epigenetic Programming of Genome Rearrangements.Annual review of genomics and human genetics · 2011Review
- The pathway to detangle a scrambled gene.PloS one · 2008Article
- Intron Evolution and Information processing in the DNA polymerase alpha gene in spirotrichous ciliates: a hypothesis for interconversion between DNA and RNA deletion.Biology direct · 2007Article
- Interconversion of germline-limited and somatic DNA in a scrambled gene.Journal of molecular evolution · 2006Article
- Conserved linkage of two genes on the same macronuclear chromosome in spirotrichous ciliates.Chromosoma · 2006Article
Corrections and comments
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Authors and funding
5 authors.
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Abstract
Some species of ciliates undergo massive DNA elimination and genome rearrangement to construct gene-sized "chromosomes" in their somatic nucleus. An example is the extensively scrambled DNA polymerase alpha gene that is broken into 48 pieces and distributed over two unlinked loci in Stylonychia. To understand the emergence of this complex phenomenon during evolution, we examined DNA polymerase alpha genes in several earlier diverging species, representing evolutionary intermediates. Mapping these data onto an evolutionary tree suggests that this gene became extensively fragmented and scrambled over evolutionary time through a series of steps, each leading to greater complexity. Our results also suggest a possible mechanism for intron loss by deletion of intron sequences as DNA during development of the somatic nucleus.
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