ArticleThe Journal of cell biology2005
Light-regulated interaction of Dmoesin with TRP and TRPL channels is required for maintenance of photoreceptors.
Article in The Journal of cell biology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 45 citations in OpenAlex.
- How filopodia respond to calcium in the absence of a calcium-binding structural protein: non-channel functions of TRP.Cell communication and signaling : CCS · 2022Article
- Knockdown of Dehydrodolichyl Diphosphate Synthase in theFrontiers in molecular neuroscience · 2021Article
- ERM Proteins at the Crossroad of Leukocyte Polarization, Migration and Intercellular Adhesion.International journal of molecular sciences · 2020Review
- Functional characterization of the three Drosophila retinal degeneration C (RDGC) protein phosphatase isoforms.PloS one · 2018Article
- Characterization of the cell polarity gene crumbs during the early development and maintenance of the squid-vibrio light organ symbiosis.Development genes and evolution · 2017Article
- Ectopic Expression of Mouse Melanopsin inThe Journal of biological chemistry · 2017Article
- Genetic architecture of natural variation in visual senescence in Drosophila.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Functional cooperation between the IP3 receptor and phospholipase C secures the high sensitivity to light of Drosophila photoreceptors in vivo.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- A new genetic model for calcium induced autophagy and ER-stress in Drosophila photoreceptor cells.Channels (Austin, Tex.) · 2015Article
- ERM proteins at a glance.Journal of cell science · 2014Article
- Drosophila TRP and TRPL are assembled as homomultimeric channels in vivo.Journal of cell science · 2013Article
- Mutation of light-dependent phosphorylation sites of the Drosophila transient receptor potential-like (TRPL) ion channel affects its subcellular localization and stability.The Journal of biological chemistry · 2013Article
- Depletion of PtdIns(4,5)P₂ underlies retinal degeneration in Drosophila trp mutants.Journal of cell science · 2013Article
- Compartmentalization and Ca2+ buffering are essential for prevention of light-induced retinal degeneration.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Ectoplasm, ghost in the R cell machine?Developmental neurobiology · 2011Review
- Translocation of the Drosophila transient receptor potential-like (TRPL) channel requires both the N- and C-terminal regions together with sustained Ca2+ entry.The Journal of biological chemistry · 2011Article
- Moesin1 and Ve-cadherin are required in endothelial cells during in vivo tubulogenesis.Development (Cambridge, England) · 2010Article
- Light-dependent phosphorylation of the drosophila transient receptor potential ion channel.The Journal of biological chemistry · 2010Article
- Knockdown of moesin expression accelerates cellular senescence of human dermal microvascular endothelial cells.Yonsei medical journal · 2010Article
- Rho1 regulates apoptosis via activation of the JNK signaling pathway at the plasma membrane.The Journal of cell biology · 2010Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
Abstract
Recent studies in Drosophila melanogaster retina indicate that absorption of light causes the translocation of signaling molecules and actin from the photoreceptor's signaling membrane to the cytosol, but the underlying mechanisms are not fully understood. As ezrin-radixin-moesin (ERM) proteins are known to regulate actin-membrane interactions in a signal-dependent manner, we analyzed the role of Dmoesin, the unique D. melanogaster ERM, in response to light. We report that the illumination of dark-raised flies triggers the dissociation of Dmoesin from the light-sensitive transient receptor potential (TRP) and TRP-like channels, followed by the migration of Dmoesin from the membrane to the cytoplasm. Furthermore, we show that light-activated migration of Dmoesin results from the dephosphorylation of a conserved threonine in Dmoesin. The expression of a Dmoesin mutant form that impairs this phosphorylation inhibits Dmoesin movement and leads to light-induced retinal degeneration. Thus, our data strongly suggest that the light- and phosphorylation-dependent dynamic association of Dmoesin to membrane channels is involved in maintenance of the photoreceptor cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.