ReviewThe Journal of cell biology2005
A(beta) generation in autophagic vacuoles.
Review in The Journal of cell biology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 51 citations in OpenAlex.
- Parishin A ameliorates cognitive decline by promoting PS1 autophagy in Alzheimer's disease.Frontiers in aging neuroscience · 2025Article
- Inhibition of NLRP1 inflammasome improves autophagy dysfunction and Aβ disposition in APP/PS1 mice.Behavioral and brain functions : BBF · 2023Article
- Ginsenoside Rg1 alleviates learning and memory impairments and Aβ disposition through inhibiting NLRP1 inflammasome and autophagy dysfunction in APP/PS1 mice.Molecular medicine reports · 2023Article
- Research Progress on Mechanism of Neuroprotective Roles of Apelin-13 in Prevention and Treatment of Alzheimer's Disease.Neurochemical research · 2022Review
- The Moringin/α-CD Pretreatment Induces Neuroprotection in an In Vitro Model of Alzheimer's Disease: A Transcriptomic Study.Current issues in molecular biology · 2021Article
- The biological pathways of Alzheimer disease: a review.AIMS neuroscience · 2021Review
- Mechanisms of action of amyloid-beta and its precursor protein in neuronal cell death.Metabolic brain disease · 2020Review
- Galantamine inhibits β-amyloid-induced cytostatic autophagy in PC12 cells through decreasing ROS production.Cell proliferation · 2018Article
- Functional analyses of major cancer-related signaling pathways in Alzheimer's disease etiology.Biochimica et biophysica acta. Reviews on cancer · 2017Review
- Autophagy and Alzheimer's Disease.Cellular and molecular neurobiology · 2017Review
- Activation of mTOR: a culprit of Alzheimer's disease?Neuropsychiatric disease and treatment · 2015Review
- Neuronal autophagy: self-eating or self-cannibalism in Alzheimer's disease.Neurochemical research · 2013Review
- Autophagy in stem cells.Autophagy · 2013Review
- APP and APLP1 are degraded through autophagy in response to proteasome inhibition in neuronal cells.Protein & cell · 2011Article
- Short-term fasting induces profound neuronal autophagy.Autophagy · 2010Article
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Alzheimer's disease (AD) is the most common form of dementia among older people. It is characterized by the extracellular accumulation of beta-amyloid (Abeta) deposits called senile or neuritic plaques. Abeta is generated by the proteolytic cleavage of Abeta precursor protein (APP) by beta and gamma-secretases localized in the secretory and endocytic compartments. In this issue, Yu et al. (on p. 87) report a novel mechanism for the generation of Abeta peptides, which takes place in autophagic vacuoles (AVs) that accumulate in AD brains.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.