Evidence map›Paper›PMID 16216007›Full record

ReviewJournal of cellular biochemistry2006

Apoptosis evasion: the role of survival pathways in prostate cancer progression and therapeutic resistance.

Shaun McKenzie, Natasha Kyprianou

Abstract readReview
In one paragraph

Review in Journal of cellular biochemistry, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers.

0numbers the graph read from it
0cells of the map it votes in
62citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

62 citing papers in PubMed.

  1. mCell death & disease · 2026
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  17. Comparative Genomics Reveals Distinct Immune-oncologic Pathways in African American Men with Prostate Cancer.Clinical cancer research : an official journal of the American Association for Cancer Research · 2021
    Article
  18. Article
  19. Article
  20. Article

2 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Shaun McKenzieDepartment of Surgery/Urology, University of Kentucky Medical Center, Lexington, KY, USA.
Natasha Kyprianou

Funding

Anoikis Effect by Quinazolines on Prostate GrowthR01CA107575 · NCI · UNIVERSITY OF KENTUCKY · PI KYPRIANOU, NATASHA · 2004 to 2008
$1.2M
TGF BETA SIGNAL TRANSDUCTION IN PROSTATE CANCERR01DK053525 · NIDDK · UNIVERSITY OF MARYLAND BALTIMORE · PI KYPRIANOU, NATASHA · 1997 to 2005
$843k
NCI NIH HHS R01 CA107575NIDDK NIH HHS R01 DK053525NIDDK NIH HHS R01 DK53525-06
6 · The paper itself

Abstract

The ability of a tumor cell population to grow exponentially represents an imbalance between cellular proliferation and cellular attrition. There is an overwhelming body of evidence suggesting the ability of tumor cells to avoid programmed cellular attrition, or apoptosis, is a major molecular force driving the progression of human tumors. Apoptotic evasion represents one of the true hallmarks of cancer and appears to be a vital component in the immunogenic, chemotherapeutic, and radiotherapeutic resistance that characterizes the most aggressive of human cancers [Hanahan and Weinberg, 2000]. The challenges in the development of effective treatment modalities for advanced prostate cancer represent a classic paradigm of the functional significance of anti-apoptotic pathways in the development of therapeutic resistance.

Indexed as

Drug Resistance, NeoplasmApoptosisDisease ProgressionHumansMaleProstatic Neoplasms

Identifiers

PMID16216007
PMCPMC2274918

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.