ArticleApoptosis : an international journal on programmed cell death2005
Intestinal intraepithelial lymphocyte derived angiotensin converting enzyme modulates epithelial cell apoptosis.
Article in Apoptosis : an international journal on programmed cell death, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16 citing papers in PubMed, 23 citations in OpenAlex.
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- Blockade of the renin-angiotensin system prevents acute and immunologically relevant colitis in murine models.Pediatric surgery international · 2016Article
- Local corticosterone production and angiotensin-I converting enzyme shedding in a mouse model of intestinal inflammation.World journal of gastroenterology · 2015Article
- Angiotensin converting enzyme-inhibitor reduces colitis severity in an IL-10 knockout model.Digestive diseases and sciences · 2013Article
- Inhibition of ACE activity contributes to the intestinal structural compensation in a massive intestinal resection rat model.Pediatric surgery international · 2012Article
- Distraction induced enterogenesis: a unique mouse model using polyethylene glycol.The Journal of surgical research · 2011Article
- Use of enterally delivered angiotensin II type Ia receptor antagonists to reduce the severity of colitis.Digestive diseases and sciences · 2011Article
- Dissociation of E-cadherin and beta-catenin in a mouse model of total parenteral nutrition: a mechanism for the loss of epithelial cell proliferation and villus atrophy.The Journal of physiology · 2009Article
- The role of angiotensin II type 1a receptor on intestinal epithelial cells following small bowel resection in a mouse model.Pediatric surgery international · 2008Article
- Article
- Modulation of mouse intestinal epithelial cell turnover in the absence of angiotensin converting enzyme.American journal of physiology. Gastrointestinal and liver physiology · 2008Article
- Intestinal epithelial cell proliferation is dependent on the site of massive small bowel resection.Pediatric surgery international · 2007Article
- Reduced severity of a mouse colitis model with angiotensin converting enzyme inhibition.Digestive diseases and sciences · 2007Article
- Influence of the site of small bowel resection on intestinal epithelial cell apoptosis.Pediatric surgery international · 2006Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
BACKGROUND &
aimsIntestinal adaptation in short bowel syndrome (SBS) consists of increased epithelial cell (EC) proliferation as well as apoptosis. Previous microarray analyses of intraepithelial lymphocytes (IEL) gene expression after SBS showed an increased expression of angiotensin converting enzyme (ACE). Because ACE has been shown to promote alveolar EC apoptosis, we examined if IEL-derived ACE plays a role in intestinal EC apoptosis.
methodsMice underwent either a 70% mid-intestinal resection (SBS group) or a transection (Sham group) and were studied at 7 days. ACE expression was measured, and ACE inhibition (ACE-I, enalaprilat) was used to assess ACE function.
resultsIEL-derived ACE was significantly elevated in SBS mice. The addition of an ACE-I to SBS mice resulted in a significant decline in EC apoptosis. To address a possible mechanism, tumor necrosis factor alpha (TNF-alpha) mRNA expression was measured. TNF-alpha was significantly increased in SBS mice, and decreased with ACE-I. Interestingly, ACE-I was not able to decrease EC apoptosis in TNF-alpha knockout mice.
conclusionsThis study shows a previously undescribed expression of ACE by IEL. SBS was associated with an increase in IEL-derived ACE. ACE appears to be associated with an up-regulation of intestinal EC apoptosis. ACE-I significantly decreased EC apoptosis.
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