ReviewMolecular neurobiology2005
bHLH genes and retinal cell fate specification.
Review in Molecular neurobiology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed.
- NeuroD4 converts glioblastoma cells into neuron-like cells through the SLC7A11-GSH-GPX4 antioxidant axis.Cell death discovery · 2023Article
- Review
- Inherited Eye Diseases with Retinal Manifestations through the Eyes of Homeobox Genes.International journal of molecular sciences · 2020Review
- Multi-site phosphorylation regulates NeuroD4 activity during primary neurogenesis: a conserved mechanism amongst proneural proteins.Neural development · 2015Article
- Prioritization of cancer-related genomic variants by SNP association network.Cancer informatics · 2015Article
- Differential responsiveness of distinct retinal domains to Atoh7.Mechanisms of development · 2014Article
- Protocadherin-17 function in Zebrafish retinal development.Developmental neurobiology · 2013Article
- Knockdown of leptin A expression dramatically alters zebrafish development.General and comparative endocrinology · 2012Article
- The chemokine receptor cxcr5 regulates the regenerative neurogenesis response in the adult zebrafish brain.Neural development · 2012Article
- Atoh8, a bHLH transcription factor, is required for the development of retina and skeletal muscle in zebrafish.PloS one · 2010Article
- Pro-photoreceptor activity of chick neurogenin1.Investigative ophthalmology & visual science · 2009Article
- Acheate-scute like 1 (Ascl1) is required for normal delta-like (Dll) gene expression and notch signaling during retinal development.Developmental dynamics : an official publication of the American Association of Anatomists · 2009Article
- Neurogenin3 promotes early retinal neurogenesis.Molecular and cellular neurosciences · 2009Article
- Identification of novel regulators of atonal expression in the developing Drosophila retina.Genetics · 2008Article
- Cadherin-6 function in zebrafish retinal development.Developmental neurobiology · 2008Article
- ISL1 and BRN3B co-regulate the differentiation of murine retinal ganglion cells.Development (Cambridge, England) · 2008Article
- Regulation of photoreceptor gene expression by Crx-associated transcription factor network.Brain research · 2008Review
- Compensational regulation of bHLH transcription factors in the postnatal development of BETA2/NeuroD1-null retina.Mechanisms of development · 2007Article
- Wnt signaling promotes regeneration in the retina of adult mammals.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2007Article
- The final fates of neurogenin2-expressing cells include all major neuron types in the mouse retina.Molecular and cellular neurosciences · 2006Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
The various cell types in the vertebrate retina arise from a pool of common progenitors. The way that the cell types are specified has been a long-standing issue. Decades of research have yielded a large body of information regarding the involvement of extrinsic factors, and only recently has the function of intrinsic factors begun to emerge. This article reviews recent studies addressing the role of basic helix-loop-helix (bHLH) factors in specifying retinal cell types, with an emphasis on bHLHhierarchies leading to photoreceptor production. Photoreceptor genesis appears to employ two transcriptional pathways: ngn2-->neuroD-->raxL and ath5-->neuroD-->raxL. ngn2 and ath5 function in progenitors, which can potentially develop into different cell types. neuroD represents one of the central steps in photoreceptor specification. Ath5 is also essential for ganglion cell development. It remains to be demonstrated whether a bHLH gene functions as a key player in specifying the other types of retinal cells. Genetic knockout studies have indicated intricate cross-regulation among bHLH genes. Future studies are expected to unveil the mechanism by which bHLH factors network with intrinsic factors and communicate with extrinsic factors to ensure a balanced production of the various types of retinal cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.