ArticleEukaryotic cell2005
Global role of the protein kinase Gcn2 in the human pathogen Candida albicans.
Article in Eukaryotic cell, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed.
- Global Stress Responses Identify the Functionally Divergent Regulators Required forExploration (Beijing, China) · 2025Article
- An integrated systems biology approach establishes arginine biosynthesis as a metabolic weakness in Candida albicans during host infection.Cell communication and signaling : CCS · 2025Article
- Reprogramming inInternational journal of molecular sciences · 2023Article
- Deletion of the Stress Response GeneJournal of fungi (Basel, Switzerland) · 2021Article
- The Transcription Factor Stp2 Is Important forFrontiers in microbiology · 2020Article
- Protein Kinases at the Intersection of Translation and Virulence.Frontiers in cellular and infection microbiology · 2019Review
- THR1 mediates GCN4 and CDC4 to link morphogenesis with nutrient sensing and the stress response in Candida albicans.International journal of molecular medicine · 2018Article
- Farnesol inhibits translation to limit growth and filamentation inMicrobial cell (Graz, Austria) · 2017Article
- Article
- Amino Acid Sensor Kinase Gcn2 Is Required for Conidiation, Secondary Metabolism, and Cell Wall Integrity in the Taxol-ProducerFrontiers in microbiology · 2017Article
- Article
- Alcohols inhibit translation to regulate morphogenesis in C. albicans.Fungal genetics and biology : FG & B · 2015Article
- Metabolism in fungal pathogenesis.Cold Spring Harbor perspectives in medicine · 2014Review
- A single inhibitory upstream open reading frame (uORF) is sufficient to regulate Candida albicans GCN4 translation in response to amino acid starvation conditions.RNA (New York, N.Y.) · 2014Article
- Rhb1 regulates the expression of secreted aspartic protease 2 through the TOR signaling pathway in Candida albicans.Eukaryotic cell · 2012Article
- The cross-pathway control system regulates production of the secondary metabolite toxin, sirodesmin PL, in the ascomycete, Leptosphaeria maculans.BMC microbiology · 2011Article
- Adaptations of Candida albicans for growth in the mammalian intestinal tract.Eukaryotic cell · 2010Article
- Rearrangements of the transcriptional regulatory networks of metabolic pathways in fungi.Current opinion in microbiology · 2009Review
- Aneuploid chromosomes are highly unstable during DNA transformation of Candida albicans.Eukaryotic cell · 2009Article
- Depletion of the cullin Cdc53p induces morphogenetic changes in Candida albicans.Eukaryotic cell · 2009Article
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Authors and funding
9 authors.
Funding
Abstract
The pathogen Candida albicans responds to amino acid starvation by activating pseudohyphal development and the expression of amino acid biosynthetic genes (GCN response). In Saccharomyces cerevisiae, the GCN response is dependent on Gcn2, which regulates the translation of the transcription factor Gcn4. Therefore, we examined the role of Gcn2 in C. albicans by using molecular, cellular, and genomic approaches. We show that C. albicans GCN2 encodes an eIF2alpha kinase, like its S. cerevisiae homologue. However, GCN4 appears to be regulated mainly at the transcriptional level in C. albicans. Furthermore, the inactivation of C. albicans Gcn2 only partially attenuates growth under amino acid starvation conditions and resistance to the histidine analogue 3-aminotriazole. Our comparison of the Gcn4 and Gcn2 regulons by transcript profiling reinforces the view that Gcn2 contributes to, but is not essential for, the activation of general amino acid control in C. albicans.
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