ArticleEukaryotic cell2005
Nuclear accumulation of the GATA factor AreA in response to complete nitrogen starvation by regulation of nuclear export.
Article in Eukaryotic cell, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.
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Who cites it
53 citing papers in PubMed, 117 citations in OpenAlex.
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- Nuclear Functions of KaeA, a Subunit of the KEOPS Complex inInternational journal of molecular sciences · 2022Article
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- Comparative Transcriptomic Analyses Reveal the Regulatory Mechanism of Nutrient Limitation-Induced Sporulation ofFoods (Basel, Switzerland) · 2022Article
- An NmrA-Like Protein, Lws1, Is Important for Pathogenesis in the Woody Plant PathogenPlants (Basel, Switzerland) · 2022Article
- Effect of Nutritional Factors and Copper on the Regulation of Laccase Enzyme Production inJournal of fungi (Basel, Switzerland) · 2021Article
- Co-option of an extracellular protease for transcriptional control of nutrient degradation in the fungus Aspergillus nidulans.Communications biology · 2021Article
- Genome-Wide Identification and Functional Characterization of GATA Transcription Factor Gene Family inJournal of fungi (Basel, Switzerland) · 2021Article
- HJournal of fungi (Basel, Switzerland) · 2021Article
- DNA affinity purification sequencing and transcriptional profiling reveal new aspects of nitrogen regulation in a filamentous fungus.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Characterization of the promoter of the nitrate transporter-encoding gene nrtA in Aspergillus nidulans.Molecular genetics and genomics : MGG · 2020Article
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- A fungal ABC transporter FgAtm1 regulates iron homeostasis via the transcription factor cascade FgAreA-HapX.PLoS pathogens · 2019Article
- The GATA-Type Transcriptional Factor Are1 Modulates the Expression of Extracellular Proteases and Cellulases inInternational journal of molecular sciences · 2019Article
- The role of the GATA transcription factor AreB in regulation of nitrogen and carbon metabolism in Aspergillus nidulans.FEMS microbiology letters · 2019Article
- Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Both the availability and the quality of nutrients affect cellular functions by controlling gene activity. AreA, a member of the GATA family of transcription factors, globally activates expression of genes involved in nitrogen source utilization in Aspergillus nidulans. The quality of the nitrogen source determines the level and activation capacity of AreA through controls at the level of areA mRNA stability and by interaction of AreA with the corepressor NmrA. The availability of potential nitrogen sources also affects the activation capacity of AreA. We show that the complete absence of a nitrogen source results in an enhanced level of AreA-dependent gene expression and that this response is independent of mechanisms regulating AreA activity in response to nitrogen source quality. During nitrogen starvation AreA accumulates in the nucleus, but the presence of a potential nitrogen source or carbon starvation prevents this accumulation. Furthermore, accumulated AreA is rapidly lost from the nuclei of nitrogen-starved cells when a nitrogen source is supplied or when a carbon source is absent, and this accompanies arrest of the AreA-dependent nitrogen starvation response on regulated gene expression. By the generation of a leptomycin B-sensitive mutant, we have been able to show that nuclear exit occurs via the CrmA exportin. We conclude that sensing mechanisms discriminate between starvation and the presence of potential nutrients that can signal to the AreA transcription factor. Nitrogen source availability, but not quality, affects nuclear accumulation by regulating nuclear exit of AreA, providing a rapid response to changes in the supply of nutrients.
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