ReviewActa neuropathologica1992
Formation of "dark" (argyrophilic) neurons of various origin proceeds with a common mechanism of biophysical nature (a novel hypothesis).
Review in Acta neuropathologica, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- A pathogenic alpha synuclein variant exacerbates disease progression in a neuron-specific Gba-KO mouse.Neurobiology of disease · 2025Article
- Deletion of Gba in neurons, but not microglia, causes neurodegeneration in a Gaucher mouse model.JCI insight · 2024Article
- Neuronal loss and gliosis in the rat striatum subjected to 15 and 30 minutes of middle cerebral artery occlusion.Metabolic brain disease · 2018Article
- Neuronal damage using fluoro-Jade B histofluorescence and gliosis in the gerbil septum submitted to various durations of cerebral ischemia.Cellular and molecular neurobiology · 2013Article
- Neuroprotective effects of tanshinone I from Danshen extract in a mouse model of hypoxia-ischemia.Anatomy & cell biology · 2013Article
- Mefloquine induces dose-related neurological effects in a rat model.Antimicrobial agents and chemotherapy · 2006Article
- Transgenic mice with Alzheimer presenilin 1 mutations show accelerated neurodegeneration without amyloid plaque formation.Nature medicine · 1999Article
- Seizure-induced neuronal injury: vulnerability to febrile seizures in an immature rat model.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1998Article
- Instantaneous perturbation of dentate interneuronal networks by a pressure wave-transient delivered to the neocortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1997Article
- Neuropathological changes caused by hydrocephalus.Acta neuropathologica · 1993Review
- An immediate light microscopic response of neuronal somata, dendrites and axons to non-contusing concussive head injury in the rat.Acta neuropathologica · 1992Article
- Light microscopic response of neuronal somata, dendrites and axons to post-mortem concussive head injury.Acta neuropathologica · 1992Article
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Authors and funding
3 authors.
Funding
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Abstract
Based on recent findings described in accompanying reports as well as on relevant observations in the literature we hypothesize that: (1) the fundamental elements in the mechanism of the formation of "dark" (argyrophilic) neurons are independent of the causative conditions including post-mortem or in vivo mechanical injuries and various in vivo pathometabolic processes such as blood recirculation following ischemia; (2) the causative conditions, each in its own mechanical or metabolic way, induce the same morphopathological damage at one point only within each affected neuron; (3) this damage spreads throughout the respective somato-dendritic or axonal domain and entails type III argyrophilia; (4) the intraneuronal spread of the morphopathological damage consumes mechanical energy stored by the neurofilaments in the form of a metastable inner structure, and (5) is propagated by a process working, in certain structural and energetical respects, on the domino principle; and (6) the primary neuronal damage caused in the above manner might be secondarily modified in different directions by different postcausation conditions.
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