ArticleBiophysical journal2006
A stochastic two-dimensional model of intercellular Ca2+ wave spread in glia.
Article in Biophysical journal, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Enteric glial S100B controls rhythmic colonic functions by regulating excitability and specificity in gut motor neurocircuits.The Journal of physiology · 2025Article
- Neurotransmission Sex Dichotomy in the Rat Hypothalamic Paraventricular Nucleus in Healthy and Infantile Spasm Model.Current issues in molecular biology · 2025Article
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- Estrogen Protects Neurotransmission Transcriptome During Status Epilepticus.Frontiers in neuroscience · 2018Article
- Computational Models for Calcium-Mediated Astrocyte Functions.Frontiers in computational neuroscience · 2018Review
- Sparse short-distance connections enhance calcium wave propagation in a 3D model of astrocyte networks.Frontiers in computational neuroscience · 2014Article
- Prenatal corticosteroids modify glutamatergic and GABAergic synapse genomic fabric: insights from a novel animal model of infantile spasms.Journal of neuroendocrinology · 2013Review
- Gap junctions and Bystander Effects: Good Samaritans and executioners.Wiley interdisciplinary reviews. Membrane transport and signaling · 2013Article
- Intercellular Ca(2+) waves: mechanisms and function.Physiological reviews · 2012Review
- Plasticity of the myelination genomic fabric.Molecular genetics and genomics : MGG · 2012Article
- Computational quest for understanding the role of astrocyte signaling in synaptic transmission and plasticity.Frontiers in computational neuroscience · 2012Article
- Biological and biophysical properties of vascular connexin channels.International review of cell and molecular biology · 2009Review
- Diffusion modeling of ATP signaling suggests a partially regenerative mechanism underlies astrocyte intercellular calcium waves.Frontiers in neuroengineering · 2008Article
- Alteration of transcriptomic networks in adoptive-transfer experimental autoimmune encephalomyelitis.Frontiers in integrative neuroscience · 2007Article
- Connexin43 and the brain transcriptome of newborn mice.Genomics · 2007Article
- Review
- Purinergic junctional transmission and propagation of calcium waves in spinal cord astrocyte networks.Biophysical journal · 2006Article
- Connexin channel permeability to cytoplasmic molecules.Progress in biophysics and molecular biologyReview
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Authors and funding
4 authors.
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Abstract
We describe a two-dimensional stochastic model of intercellular Ca(2+) wave (ICW) spread in glia that includes contributions of external stimuli, ionotropic and metabotropic P2 receptors, exo- and ecto-nucleotidases, second messengers, and gap junctions. In this model, an initial stimulus evokes ATP and UTP release from a single cell. Agonists diffuse and are degraded both in bulk solution and at cell surfaces. Ca(2+) elevation in individual cells is determined by bound agonist concentrations s and by number and features of P2 receptors summed with that generated by IP(3) diffusing through gap junction channels. Variability of ICWs is provided by randomly distributing a predetermined density of cells in a rectangular grid and by randomly selecting within intervals values characterizing the extracellular compartment, individual cells, and interconnections with neighboring cells. Variability intervals were obtained from experiments on astrocytoma cells transfected to express individual P2 receptors and/or the gap junction protein connexin43. The simulation program (available as Supplementary Material) permits individual alteration of ICW components, allowing comparison of simulations with data from cells expressing connexin43 and/or various P2 receptor subtypes. Such modeling is expected to be useful for testing phenomenological hypotheses and in understanding consequences of alteration of system components under experimental or pathological conditions.
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