ArticleJournal of feline medicine and surgery2006
Inhaled fluticasone reduces bronchial responsiveness and airway inflammation in cats with mild chronic bronchitis.
Article in Journal of feline medicine and surgery, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
14 citing papers in PubMed, 45 citations in OpenAlex.
- Use of a Capsaicin Cough Challenge Test to Compare Four Different Techniques for Nebulization Delivery in Cats.Veterinary sciences · 2024Article
- Comparative Study of Inhaled Fluticasone Versus Oral Prednisone in 30 Dogs with Cough and Tracheal Collapse.Veterinary sciences · 2023Article
- Breathe easy: inhalational therapy for feline inflammatory airway disease.Journal of feline medicine and surgery · 2023Review
- Prospective evaluation of the efficacy of inhaled steroids administered via the AeroDawg spacing chamber in management of dogs with chronic cough.Journal of veterinary internal medicine · 2023Article
- Reactions to environmental allergens in cats with feline lower airway disease.Frontiers in veterinary science · 2023Article
- Evaluation of barometric whole-body plethysmography for therapy monitoring in cats with feline lower airway disease.PloS one · 2022Article
- Simultaneous visual inspection for barometric whole-body plethysmography waveforms during pulmonary function testing in client-owned cats.Journal of feline medicine and surgery · 2016Article
- Pulmonary function in obese vs non-obese cats.Journal of feline medicine and surgery · 2015Article
- Functional phenotype and its correlation with therapeutic response and inflammatory type of bronchoalveolar lavage fluid in feline lower airway disease.Journal of veterinary internal medicine · 2015Article
- Functional assessment of expiratory flow pattern in feline lower airway disease.Journal of feline medicine and surgery · 2014Article
- Feline asthma: what's new and where might clinical practice be heading?Journal of feline medicine and surgery · 2010Review
- Effects of fluticasone propionate dosage in an experimental model of feline asthma.Journal of feline medicine and surgery · 2010Article
- Glucose lowering effects of inhaled insulin in healthy cats.Journal of feline medicine and surgery · 2008Article
- Correlation of clinical and radiographic variables in cats with lower airway disease.Journal of veterinary internal medicineArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study investigated the effect of inhaled fluticasone on lower airway inflammation and bronchial responsiveness (BR) to inhaled carbachol in cats with very mild, chronic bronchitis (n = 5) that were compared with healthy cats serving as controls (n = 6). Chest radiographs, BR tests performed non-invasively by barometric whole body plethysmography (BWBP) and bronchoalveolar lavage (BAL) were performed before and after treatment. BR was quantified by calculating the concentration of carbachol inducing bronchoconstriction (C-Penh300%), defined as a 300% increase of baseline Penh, an index of bronchoconstriction obtained by BWBP. BAL fluid was analyzed cytologically and the oxidant marker 8-iso-PGF2alpha was determined. At test 1, healthy cats and cats with bronchitis were untreated, whereas for test 2 inhalant fluticasone (250 microg once daily) was administrated for 2 consecutive weeks to cats with bronchitis. Control cats remained untreated. Inhaled fluticasone induced a significant increase in C-Penh300% and a significant decrease of BAL fluid total cells, macrophages, neutrophils and 8-iso-PGF2alpha in cats with bronchitis, whilst untreated control cats did not show significant changes over time. This study shows that a 2-week fluticasone treatment significantly reduced lower airway inflammation in very mild bronchitis. BR could be successfully monitored in cats using BWPB and decreased significantly in response to inhaled fluticasone. 8-Iso-PGF2alpha in BAL fluid was responsive to treatment and appeared as a sensitive biomarker of lower airway inflammation in cats.
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