ArticleBMC cancer2005
Modeling the effect of age in T1-2 breast cancer using the SEER database.
Article in BMC cancer, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Post-mastectomy radiotherapy for breast cancer patients with t1-t2 and 1-3 positive lymph nodes: a meta-analysis.PloS one · 2013Pooled it
- What Is Known about Breast Cancer in Young Women?Cancers · 2023Review
- Update and validation of a diagnostic model to identify prevalent malignant lesions in esophagus in general population.EClinicalMedicine · 2022Article
- Gini's mean difference and the long-term prognostic value of nodal quanta classes after pre-operative chemotherapy in advanced breast cancer.Scientific reports · 2022Article
- Refining breast cancer prognosis by incorporating age at diagnosis into clinical prognostic staging: introduction of a novel online calculator.Breast cancer research and treatment · 2021Article
- The Prognostic Impact of Age at Diagnosis Upon Breast Cancer of Different Immunohistochemical Subtypes: A Surveillance, Epidemiology, and End Results (SEER) Population-Based Analysis.Frontiers in oncology · 2020Article
- A population-based cohort of young women diagnosed with breast cancer in Geneva, Switzerland.PloS one · 2019Article
- A comparison of breast cancer survival among young, middle-aged, and elderly patients in southern Iran using Cox and empirical Bayesian additive hazard models.Epidemiology and health · 2017Article
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- Health and economic impact of breast cancer mortality in young women, 1970-2008.American journal of preventive medicine · 2014Article
- Effects of iron deficiency and iron overload on angiogenesis and oxidative stress-a potential dual role for iron in breast cancer.Free radical biology & medicine · 2011Article
- Age and axillary lymph node ratio in postmenopausal women with T1-T2 node positive breast cancer.The oncologist · 2010Article
- Article
- Chemotherapy: Adjuvant chemotherapy in older patients with breast cancer.Nature reviews. Clinical oncology · 2009Article
- Accelerated partial-breast irradiation (APBI)--ready for prime time?Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] · 2009Article
- Basal phenotype in breast carcinoma occurring in women aged 35 or younger.Pathology oncology research : POR · 2009Article
- The effect of adjuvant radiotherapy on mortality differs according to primary tumor location in women with node-positive breast cancer.Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] · 2009Article
- Does iron have a role in breast cancer?The Lancet. Oncology · 2008Review
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundModeling the relationship between age and mortality for breast cancer patients may have important prognostic and therapeutic implications.
methodsData from 9 registries of the Surveillance, Epidemiology, and End Results Program (SEER) of the United States were used. This study employed proportional hazards to model mortality in women with T1-2 breast cancers. The residuals of the model were used to examine the effect of age on mortality. This procedure was applied to node-negative (N0) and node-positive (N+) patients. All causes mortality and breast cancer specific mortality were evaluated.
resultsThe relationship between age and mortality is biphasic. For both N0 and N+ patients among the T1-2 group, the analysis suggested two age components. One component is linear and corresponds to a natural increase of mortality with each year of age. The other component is quasi-quadratic and is centered around age 50. This component contributes to an increased risk of mortality as age increases beyond 50. It suggests a hormonally related process: the farther from menopause in either direction, the more prognosis is adversely influenced by the quasi-quadratic component. There is a complex relationship between hormone receptor status and other prognostic factors, like age.
conclusionThe present analysis confirms the findings of many epidemiological and clinical trials that the relationship between age and mortality is biphasic. Compared with older patients, young women experience an abnormally high risk of death. Among elderly patients, the risk of death from breast cancer does not decrease with increasing age. These facts are important in the discussion of options for adjuvant treatment with breast cancer patients.
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