ArticleJournal of molecular evolution2005
Error minimization and coding triplet/binding site associations are independent features of the canonical genetic code.
Article in Journal of molecular evolution, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Design of overlapping genes using deep generative models of protein sequences.bioRxiv : the preprint server for biology · 2025Article
- Symmetrical distributions of aminoacyl-tRNA synthetases during the evolution of the genetic code.Theory in biosciences = Theorie in den Biowissenschaften · 2023Article
- Little Evidence the Standard Genetic Code Is Optimized for Resource Conservation.Molecular biology and evolution · 2021Article
- Fitting the standard genetic code into its triplet table.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- First arrived, first served: competition between codons for codon-amino acid stereochemical interactions determined early genetic code assignments.Die Naturwissenschaften · 2020Article
- Phenotypic Graphs and Evolution Unfold the Standard Genetic Code as the Optimal.Origins of life and evolution of the biosphere : the journal of the International Society for the Study of the Origin of Life · 2018Article
- The Genetic Code and RNA-Amino Acid Affinities.Life (Basel, Switzerland) · 2017Review
- A unified model of the standard genetic code.Royal Society open science · 2017Article
- A realistic model under which the genetic code is optimal.Journal of molecular evolution · 2013Article
- Exceptional error minimization in putative primordial genetic codes.Biology direct · 2009Article
- RNA-amino acid binding: a stereochemical era for the genetic code.Journal of molecular evolution · 2009Review
- A four-column theory for the origin of the genetic code: tracing the evolutionary pathways that gave rise to an optimized code.Biology direct · 2009Article
- Origin and evolution of the genetic code: the universal enigma.IUBMB life · 2009Review
- One ancestor for two codes viewed from the perspective of two complementary modes of tRNA aminoacylation.Biology direct · 2009Article
- On the physical basis of the amino acid polar requirement.Journal of molecular evolution · 2008Article
- Evolution of the genetic code: partial optimization of a random code for robustness to translation error in a rugged fitness landscape.Biology direct · 2007Article
- In silico detection of tRNA sequence features characteristic to aminoacyl-tRNA synthetase class membership.Nucleic acids research · 2007Article
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Authors and funding
3 authors.
Funding
Abstract
The canonical genetic code has been reported both to be error minimizing and to show stereochemical associations between coding triplets and binding sites. In order to test whether these two properties are unexpectedly overlapping, we generated 200,000 randomized genetic codes using each of five randomization schemes, with and without randomization of stop codons. Comparison of the code error (difference in polar requirement for single-nucleotide codon interchanges) with the coding triplet concentrations in RNA binding sites for eight amino acids shows that these properties are independent and uncorrelated. Thus, one is not the result of the other, and error minimization and triplet associations probably arose independently during the history of the genetic code. We explicitly show that prior fixation of a stereochemical core is consistent with an effective later minimization of error.
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