ArticlePediatric nephrology (Berlin, Germany)2006
Effect of tumor necrosis factor alpha and vascular permeability growth factor on albuminuria in rats.
Article in Pediatric nephrology (Berlin, Germany), 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
6 citing papers in PubMed, 16 citations in OpenAlex.
- Randomized controlled trial on immunomodulatory effects of azithromycin in children with steroid-dependent nephrotic syndrome.Pediatric nephrology (Berlin, Germany) · 2019Trial
- The Role of TNF-α in the Pathogenesis of Idiopathic Nephrotic Syndrome and Its Usefulness as a Marker of the Disease Course.Journal of clinical medicine · 2024Article
- Pathogenesis of childhood idiopathic nephrotic syndrome: a paradigm shift from T-cells to podocytes.World journal of pediatrics : WJP · 2015Review
- The role of the immune system in idiopathic nephrotic syndrome: a review of clinical and experimental studies.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2014Review
- Clinicopathological study of glomerular diseases associated with sarcoidosis: a multicenter study.Orphanet journal of rare diseases · 2013Article
- A case of unfulfilled expectations. Cytokines in idiopathic minimal lesion nephrotic syndrome.Pediatric nephrology (Berlin, Germany) · 2006Review
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The purposes of this study were to measure the serum levels of vascular permeability growth factor (VPGF) and tumor necrosis factor alpha (TNFalpha) in minimal lesion nephrotic syndrome (MLNS) patients and to assess their effect on albuminuria in rats. Serum for VPGF and TNFalpha was obtained during relapse and remission from 18 MLNS patients. Tumor necrosis factor alpha was infused at the rate of 10 and 20 ng/h and VPGF at the rate of 20 and 40 ng/h for 5 days into the left renal artery of rats. Urinary albumin (24-h collection) was measured prior to infusion and on days 2, 4 and 5. Rats infused with 1% bovine serum albumin served as controls. Serum VPGF and TNFalpha levels in MLNS patients in relapse were not different from those seen during remission. A significant increase in albuminuria was observed on day 4 and 5 only when rats were infused with TNFalpha at the rate of 20 ng/h as compared to the excretion seen in same animals prior to the infusion of cytokine and on days 4 and 5 of normal controls. Neither VPGF nor TNFalpha seems to be the circulating pathogenic cytokine for proteinuria in MLNS. However, TNFalpha may contribute to the increased albuminuria via a paracrine effect at the glomerulus.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.