ArticleJournal of gastroenterology2005
Helicobacter pylori infection increases the risk of colorectal adenoma and adenocarcinoma, especially in women.
Article in Journal of gastroenterology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 5 of them syntheses that pooled it.
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Who cites it
34 citing papers in PubMed, 5 syntheses or guidelines pooled it, 80 citations in OpenAlex.
- Association BetweenFrontiers in medicine · 2021Pooled it
- Association between Helicobacter pylori infection and the risk of colorectal cancer: A systematic review and meta-analysis.Medicine · 2020Pooled it
- Risk for Colorectal Neoplasia in Patients With Helicobacter pylori Infection: A Systematic Review and Meta-analysis.Clinical and translational gastroenterology · 2020Pooled it
- Helicobacter pylori infection increases the risk of colorectal adenomas: cross-sectional study and meta-analysis.Digestive diseases and sciences · 2012Pooled it
- Meta-analysis of different test indicators: Helicobacter pylori infection and the risk of colorectal cancer.International journal of colorectal disease · 2008Pooled it
- Beyond the Stomach: Exploring the Role ofExpert reviews in molecular medicine · 2026Review
- Helicobacter Pylori Infection is Not Causally Associated with Colorectal Cancer: A Two-Sample Mendelian Randomization Study.Asian Pacific journal of cancer prevention : APJCP · 2025Article
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- Increased risk of colorectal adenoma and benign colorectal polyp associated withTranslational cancer research · 2025Article
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- Interaction between microbiota and immunity and its implication in colorectal cancer.Frontiers in immunology · 2022Review
- Prevalence of Helicobacter pylori among Sudanese patients diagnosed with colon polyps and colon cancer using immunohistochemistry technique.BMC research notes · 2020Article
- Endoscopic gastric mucosal atrophy as a predictor of colorectal polyps: a large scale case-control study.Journal of clinical biochemistry and nutrition · 2019Article
- Helicobacter pylori and colorectal cancer-A bacterium going abroad?PLoS pathogens · 2019Article
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- Helicobacter pylori is associated with increased risk of serrated colonic polyps: Analysis of serrated polyp risk factors.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2018Article
- Association of Helicobacter pylori Infection With Colon Cancer and Adenomatous Polyps.Iranian journal of pathology · 2018Article
- Microbiota, Inflammation and Colorectal Cancer.International journal of molecular sciences · 2017Review
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- Article
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Authors and funding
14 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundRecent reports suggest that Helicobacter pylori infection can potentially increase the risk of colorectal cancer. The purpose of this study was to assess the association between H. pylori infection and the risk of colorectal adenoma and adenocarcinoma, and to evaluate any differences on the basis of sex.
methodsThe subjects were 669 (40- to 80-year-old) patients who underwent both barium enema examination and total colonoscopy, and who were evaluated for H. pylori infection by (13)C-urea breath test, urease test, or histological diagnosis of biopsied gastric specimens. There were 142 H. pylori-negative and 527-positive patients. The odds ratios (ORs) for H. pylori-positive patients with colorectal adenoma and adenocarcinoma, and for tumor patients with either adenoma or adenocarcinoma were calculated.
resultsAmong the H. pylori-negative patients, there were 52 patients without tumor, 63 with adenoma, 27 with adenocarcinoma, and 90 with tumor. Among the H. pylori-positive patients, there were 136, 264, 127, and 391 patients respectively. Pooling all subjects, those infected with H. pylori had a significantly increased OR for adenoma, adenocarcinoma, or tumor, compared to H. pylori-free patients (OR, 1.60, 1.80, and 1.66, respectively). For female H. pylori-positive subjects, the risk of having adenocarcinoma or tumor was significantly higher than that for their H. pylori-free counterparts, while for male H. pylori-positive and -negative subjects, there was no such significant difference.
conclusionsThe results therefore suggest that, in patients aged 40-80 years, H. pylori infection increased the risk of colorectal adenoma and adenocarcinoma, with significantly higher risks for female patients.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.