ArticleThe American journal of clinical nutrition2005
Arterial endothelial dysfunction in baboons fed a high-cholesterol, high-fat diet.
Article in The American journal of clinical nutrition, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 37 citations in OpenAlex.
- Hepatic Inflammation Primes Vascular Dysfunction Following Treatment with LPS in a Murine Model of Pediatric Fatty Liver Disease.International journal of molecular sciences · 2025Article
- A first case of hepatocellular carcinoma in the baboon (Papio spp.) placenta.Journal of medical primatology · 2019Article
- Use and Importance of Nonhuman Primates in Metabolic Disease Research: Current State of the Field.ILAR journal · 2017Review
- Review
- An ethanol root extract of Cynanchum wilfordii containing acetophenones suppresses the expression of VCAM-1 and ICAM-1 in TNF-α-stimulated human aortic smooth muscle cells through the NF-κB pathway.International journal of molecular medicine · 2015Article
- Early endothelial damage detected by circulating particles in baboons fed a diet high in simple carbohydrates in conjunction with saturated or unsaturated fat.American journal of cardiovascular disease · 2014Article
- Longitudinal analysis of short-term high-fat diet on endothelial senescence in baboons.American journal of cardiovascular disease · 2013Article
- Repertoire of endothelial progenitor cells mobilized by femoral artery ligation: a nonhuman primate study.Journal of cellular and molecular medicine · 2012Article
- Profound influence of LDL oxidative status and monocyte co-cultures on baboon endothelial activation.American journal of cardiovascular disease · 2012Article
- Western diet enhances hepatic inflammation in mice exposed to cecal ligation and puncture.BMC physiology · 2010Article
- Genetic regulation of endothelial inflammatory responses in baboons.Arteriosclerosis, thrombosis, and vascular biology · 2010Article
- CCl4-induced hepatic injury in mice fed a Western diet is associated with blunted healing.Journal of gastroenterology and hepatology · 2010Article
- Molecular pathways mediating differential responses to lipopolysaccharide between human and baboon arterial endothelial cells.Clinical and experimental pharmacology & physiology · 2010Article
- A model of cardiovascular disease giving a plausible mechanism for the effect of fractionated low-dose ionizing radiation exposure.PLoS computational biology · 2009Article
- Differential bone marrow stem cell mobilization by G-CSF injection or arterial ligation in baboons.Journal of cellular and molecular medicine · 2009Article
- [Not Available].Pathophysiology : the official journal of the International Society for Pathophysiology · 2008Article
- Knockout of TRPV1 Exacerbates Ischemia-reperfusion-induced Renal Inflammation and Injury in Obese Mice.In vivo (Athens, Greece)Article
- Evaluation of vascular smooth muscle and corpus cavernosum on hypercholesterolemia. Is resveratrol promising on erectile dysfunction?International journal of impotence researchArticle
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundEndothelial dysfunction signals the initiation and progression of atherosclerosis. Elevated LDL-cholesterol concentrations have been suggested to induce endothelial dysfunction, but direct in vivo evidence for the relation is still lacking.
objectiveWe examined the hypothesis that a high-cholesterol, high-fat (HCHF) diet can directly cause endothelial dysfunction in vivo.
designWe measured inflammatory and endothelial dysfunctional markers in circulating blood and directly in endothelial cells, which were collected by femoral artery biopsies, in 10 baboons before and after a 7-wk HCHF dietary challenge.
resultsWe found that the HCHF diet induced a high inflammatory status, as indicated by increased concentrations of interleukin 6, tumor necrosis factor alpha (TNF-alpha), and monocyte chemoattractant protein 1. Although the concentrations of endothelial dysfunctional markers, such as soluble vascular cell adhesion molecule 1 (VCAM-1) and intercellular adhesion molecule 1, were not increased by the HCHF diet, membrane-bound VCAM-1 and membrane-bound E-selectin on endothelial cells were highly increased after 7 wk of the HCHF diet (P < 0.01). In contrast, the concentrations of endothelial nitric oxide synthase in endothelial cells were significantly reduced by the 7-wk HCHF diet (P < 0.01). Furthermore, the dietary challenge attenuated endothelial cell responses to TNF-alpha, lipopolysaccharide, native LDL cholesterol, and oxidized LDL-cholesterol stimulation.
conclusionsOur results show that an HCHF diet can directly induce inflammation and endothelial dysfunction. Prior in vivo exposure to an HCHF diet attenuates the in vitro responses of endothelial cells to atherogenic risk factors. This preconditioning phenomenon may have significant clinical relevance.
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