ArticleClinical and diagnostic laboratory immunology2005
Evaluation of LIAISON Treponema Screen, a novel recombinant antigen-based chemiluminescence immunoassay for laboratory diagnosis of syphilis.
Article in Clinical and diagnostic laboratory immunology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
22 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Sensitivity and Specificity of Treponemal-specific Tests for the Diagnosis of Syphilis.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2020Pooled it
- The Traditional or Reverse Algorithm for Diagnosis of Syphilis: Pros and Cons.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2020Pooled it
- CDC Laboratory Recommendations for Syphilis Testing, United States, 2024.MMWR. Recommendations and reports : Morbidity and mortality weekly report. Recommendations and reports · 2024Article
- Evaluate performance of the Abbott chemiluminescent microparticle immunoassay assay for detection of syphilis infection in Chinese blood donors.Journal of clinical laboratory analysis · 2020Article
- An electrochemical scaffold sensor for rapid syphilis diagnosis.The Analyst · 2019Article
- The analyzation and clinical evaluation of ECLIA and CMIA in the detection of Treponema pallidum.Medicine · 2017Article
- Observational
- Clinical Evaluation of Fully Automated ElecsysJournal of clinical laboratory analysis · 2016Article
- Contribution of a Comparative Western Blot Method to Early Postnatal Diagnosis of Congenital Syphilis.Clinical and vaccine immunology : CVI · 2016Article
- Evaluation of the HISCL Anti-Treponema pallidum Assay as a Screening Test for Syphilis.Clinical and vaccine immunology : CVI · 2015Article
- Evaluation of the Vitros Syphilis TPA chemiluminescence immunoassay as a first-line method for reverse syphilis screening.Journal of clinical microbiology · 2015Article
- Performance evaluation of the Elecsys syphilis assay for the detection of total antibodies to Treponema pallidum.Clinical and vaccine immunology : CVI · 2015Article
- The endemic treponematoses.Clinical microbiology reviews · 2014Review
- Evaluation of the BioPlex 2200 syphilis system as a first-line method of reverse-sequence screening for syphilis diagnosis.Clinical and vaccine immunology : CVI · 2013Article
- A protein concentration measurement system using a flexural plate-wave frequency-shift readout technique.Sensors (Basel, Switzerland) · 2012Article
- It is time to use treponema-specific antibody screening tests for diagnosis of syphilis.Journal of clinical microbiology · 2012Article
- Evaluation of a new chemiluminescence immunoassay for diagnosis of syphilis.European journal of medical research · 2010Article
- Article
- Laboratory diagnosis of syphilis with automated immunoassays.Journal of clinical laboratory analysis · 2009Article
- Evaluation of the LIAISON chemiluminescence immunoassay for diagnosis of syphilis.Clinical and vaccine immunology : CVI · 2007Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The purpose of this study was to evaluate the diagnostic performance of LIAISON Treponema Screen (DiaSorin, Saluggia, Italy), a new automated chemiluminescence immunoassay (CLIA), in comparison with that of rapid plasma reagin (RPR) and the following currently used treponemal tests: hemagglutination test (TPHA), immunoenzymatic assay (EIA), and Western blot (WB). First, a retrospective study was performed with a panel of 2,494 blood donor sera, a panel of 131 clinical and serologically characterized syphilitic sera, and 96 samples obtained from subjects with potentially interfering diseases or conditions. A prospective study was also performed by testing 1,800 unselected samples submitted to the Microbiology Laboratory of the St. Orsola Hospital in Bologna, Italy, for routine screening for syphilis. As expected, RPR was the least specific method, especially when potentially cross-reacting sera were tested. On the contrary, all of the treponemal tests proved to be very specific (99.9%) and they performed with the following sensitivities: 100% (WB), 99.2% (CLIA), 95.4% (EIA), and 94.7% (TPHA).
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